ObjectivesThis study described the population structure of M. tuberculosis complex (MTBc) strains among patients with pulmonary or lymph node (TB) in Northwest Ethiopia and tested performance culture isolation MPT64-based speciation for Lineage 7 (L7).MethodsPatients were recruited between April 2017 June 2019 North Gondar, Ethiopia. The MPT64 assay was used to confirm MTBc, spoligotyping chara...

Treatment of multidrug-resistant (MDR) tuberculosis (TB) (defined as resistance to at least isoniazid and rifampicin, two core first-line drugs for TB treatment) and extensively drug-resistant (XDR)-TB (defined as resistance to isoniazid and rifampicin plus any fluoroquinolone and at least one of the injectable drugs amikacin, capreomycin or kanamycin) are a challenge for both clinicians and pu...

Introduction: One of the main reasons for the development of the resistance in the therapy for Tuberculosis is the mono drug therapy. This may be due to the drug-drug interactions as the therapy includes combination of various drugs leading to poor bioavailability of these drugs. One such reported interaction is between Rifampicin and Isoniazid which leads to poor bioavailability of Rifampicin....

A cross-sectional descriptive study was carried out at a tuberculosis center, Yangon, Myanmar from October 2003 to July 2004 to analyze the drug susceptibility of new sputum smear positive pulmonary tuberculosis patients. A total of 202 Mycobacterium tuberculosis isolates were tested for resistance to isoniazid, streptomycin, rifampicin and ethambutol. Resistance to at least one anti-tuberculos...

We set out to determine the levels of Mycobacterium tuberculosis resistance to first- and second-line TB drugs in an urban population in Zambia. Sputum samples were collected consecutively from all smear-positive, new and previously treated patients, from four diagnostic centres in Ndola between January and July 2006. Drug susceptibility testing was performed using the proportion method against...

BACKGROUND Surveillance and effective management of drug resistance is important to sustaining tuberculosis (TB) control efforts. We aimed to determine resistance rates to first line anti tuberculosis drugs and to describe factors associated with the resistance to any of the first line anti tuberculosis drugs in Dar es Salaam Tanzania. MATERIALS Newly diagnosed, TB patients with neither histo...

Objective: In the study, 419 Mycobacterium tuberculosis complex strains (MTC), which were isolated from samples sent to Regional Tuberculosis Laboratory in our city between 2015 and 2019 with suspected Erzurum surrounding cities investigated. Methods: Our research is a retrospective cross-sectional study clinical Public Health suspicion of within five-year period January December first evaluate...

To the Editor: Resistance of Mycobacterium tuberculosis to the commonly used antibiotics in national tuberculosis programmes (NTPs) is a growing concern in many parts of the world. 1 Nevertheless there is much anecdotal, but little published, evidence that drug resistance is becoming an important barrier to effective TB control. 2 In Zimbabwe the only routine source of data on drug resistance t...

Multiplex allele-specific PCRs detecting katG codon 315 and mabA (bp -15) mutations could specifically identify 77.5% of isoniazid-resistant Mycobacterium tuberculosis strains in the South China region. One clinical isolate harboring InhA Ile194Thr was characterized to show strong association with isoniazid resistance in Mycobacterium tuberculosis.

To determine patient characteristics associated with isoniazid resistance in cases of tuberculous meningitis, we conducted a cross-sectional study by using data from the US National Tuberculosis Surveillance System during 1993-2005. Foreign-born patients were more likely to be infected with an isoniazid-resistant strain.