Exercise training induces muscular adaptations that are highly specific to the type of exercise. For a systematic study of the differentiated exercise adaptations on a molecular level mouse models have been used successfully. The aim of the current study was to develop a suitable mouse model of isometric strength exercise training characterized by specific adaptations known from strength traini...

Changes induced in left ventricular (LV) hemodynamics by isometric exercise were analyzed in 43 patients: 30 with coronary heart disease (CAD), four with noncoronary heart disease, nine normal. Volumes were angiographically determined and correlated with left ventricular end-diastolic pressure (LVEDP) both at rest and during the fifth minute of 30% sustained handgrip (HNG). All normals and eigh...

The effects of dynamic and intermittent isometric knee extension exercises on skeletal muscle blood flow and flow heterogeneity were studied in seven healthy endurance-trained men. Regional muscle blood flow was measured using positron emission tomography (PET) and an [(15)O]H(2)O tracer, and electromyographic (EMG) activity was recorded in the quadriceps femoris (QF) muscle during submaximal i...

A cholinergic (muscarinic) contribution to the initial circulatory response to exercise in humans remains controversial. Herein, we posit that this may be due to exercise mode with a cholinergic contribution being important during isometric handgrip exercise, where the hyperemic response of the muscle is relatively small compared with the onset of leg cycling, where a marked increase in muscle ...

STUDY DESIGN Randomized pretest-posttest control group design. OBJECTIVES To determine the intratester and intertester reliability of a modified isometric stability test and to use this test to evaluate the effects of practice following a 4-week stabilization exercise program with weekly reinstruction. BACKGROUND Although "stabilization" exercise programs are commonplace in the clinic, the ...

OBJECTIVE The purpose of the current study was to quantitatively examine the muscle activations of 3 common isometric core exercises (abdominal bridge, single-leg abdominal bridge, and superman) along with a newly introduced isometric exercise (flying squirrel) and determine if muscle activations differed among the exercises. DESIGN The design was a comparison study. SETTING An athletic tra...

PURPOSE To determine whether nifedipine, an L-type calcium channel blocker, alters choroidal blood flow (ChBF) regulation during isometric exercise in healthy subjects. METHODS The study was carried out in a randomized, placebo-controlled, double-masked, two-way crossover design. Fifteen healthy male subjects were randomly assigned to receive either placebo or nifedipine on two different stud...

It is known that sport-specific remodeling of the heart may occur with exercise. Although some overlap exists, exercise activity can be segregated into 2 forms: isotonic exercise (endurance training) and isometric exercise (strength training), with defining hemodynamic differences. Increased cardiac output leads to a volume challenge that occurs with isotonic exercise that affects all 4 heart c...