Crescente, M., Pluthero , F. G., Li, L., Lo, R. W., Walsh, T. G., Schenk, M. P., Holbrook, L. M., Loureiro, S., Ali, M. S., Vaiyapuri, S., Falet, H., Jones, I. M., Poole, A. W., Kahr, W. H. A. and Gibbins, J. M. (2016) Intracellular trafficking, localization, and mobilization of platelet-borne thiol isomerases. Arteriosclerosis Thrombosis and Vascular Biology, 36 (6). pp. 1164-1173. ISSN 1079-5...

T he natural prostanoids arise from the activity of intracellular cyclo-oxygenase (COX) on polyunsaturated fatty acids released from membrane phospholipids. In the case of the most important substrate, arachidonic acid (20:4ω6), the first product is prostaglandin G2 (PGG2), which is then reduced to PGH2 by an associated 15-hydroperoxidase [1]. Depending on the tissue, PGH2 may be further metabo...