A new degradant of Nafcillin Sodium was found at a level of 1.8% w/w during the gradient reversed-phase HPLC analysis in stability storage samples. This impurity was identified by LC-MS and was characterized by (1)H-NMR, (13)C-NMR, LC/MS/MS, elemental analysis, and IR techniques. Based on the structural elucidation data, this impurity was named as N-[(2S)-2-carboxy-2-{[(2-ethoxynaphthalen-1-yl)...

Recently we reported') the isolation and structural elucidation of a SAKAGUCHI-positive metabolite of Streptomyces, found in the course of chemical screening of microbial metabolites. The compound proved to be identical to antipain=' discovered as a protease inhibitor. In the present paper, we wish to report the isolation of another SAKAGUCHI-positive metabolite, KF77-AG6, which corresponds to ...

griseoaurantiacus SANK63479. In this paper, we report the isolation procedure and structural elucidation of griseolic acids B2) and C3). Griseolic acids B and C were separated from the mother liquid of griseolic acid A by Sephadex G-10 column chromatography. The mother liquid was dissolved in water and applied on Sephadex G-10 column and developed with water. Two active fractions (griseolic aci...

The isolation, structural elucidation and biological activities of oligosporon (1), oligosporol A (2) and oligosporol B (3), three new antibiotics from cultures of the predacious deuteromycete, Arthrobotrys oligospora, are reported. The structures were elucidated by means of high resolution mass and high field N M R spectroscopy. The compounds exhibited weak antimicro­ bial, cytotoxic and hemol...

Chemical investigation of the fruiting bodies of Ganoderma hainanense resulted in isolation of fourteen lanostane triterpenoids, including nine ganoderma acids and five ganoderma alcohols, together with five known compounds. Structural elucidation was determined using extensive spectroscopic technologies, Mosher's method and X-ray single crystal diffraction. Three of the compounds showed inhibi...

found a strain of Sphingomonas sp. that produced a novel pentapeptide exhibiting high algaecidal activity against Microcystis spp. This communication describes the isolation and the structural elucidation of the active compound, argimicin A (1). The producer was isolated from a water sample containing colonies of Microcystis sp. collected at Lake Biwa, and was classified into Sphingomonas sp. b...