FEW theories about diabetes gain universal acceptance, and the role attributed to the pancreas varies from a major to a very minor one in the opinions of different groups of workers. Two facts that are generally accepted are that diabetes can be caused by pancreatectomy, and that its symptoms can be alleviated by insulin administration. The relative lack of insulin which is implied by these two...

Transthyretin (TTR) is a major amyloid fibril protein in certain systemic forms of amyloidosis. It is a plasma protein, mainly synthesized by the liver but expression occurs also at certain minor locations, including the endocrine cells in the islets of Langerhans. With the use of immunohistochemistry and in situ hybridization, we have studied the distribution of transthyretin-containing cells ...

Creation of a bioartificial pancreas, including cell-engineered construct (CEC) formed from pancreatic islets (islets Langerhans) and biocompatible matrix mimicking the native microenvironment tissue, is one approaches to treatment type 1 diabetes mellitus (T1D). Objective: conduct preliminary in vivo studies functional efficacy intraperitoneal injection endocrine suspension rat an experimental...

......................................................................................................... 139

TABLE 1 Landmarks in the history of the islets of Langerhans 1869 First description of pancreatic islets by Langerhans 1902 First tumour of the islets described by Nicholls 1922 Discovery of insulin by Banting and Best 1923 Discovery of glucagon by Murlin and colleagues 1924 Harris postulates the possibility of insulinoma 1927 Wilder extracts insulin from a malignant pancreatic tumour explored ...

We review here the macrophages found in endocrine tissues, placing emphasis on those residing in the islets of Langerhans of the pancreas. The islets represent the endocrine organ where macrophages have been examined in great detail and where our own studies and experience have been directed.

Here we present a convenient method for easy hand selection of enzymatically isolated small tissues such as islets of Langerhans. Islets are continuously collected in a micropipette tip connected to a peristaltic pump. After entering the conical micropipette tip, the islets are quickly dragged up by solution flow, but this movement subsequently decreases as the flow rate decreases. Thus, the is...