Isatin and its metabolites are constituents of many natural substances. They are also components of many synthetic compounds exhibiting a wide range of effects, including antiviral activity, antitumor and antiangiogenic activity, antibacterial, antitubercular, antifungal, antiaptotic, anticonvulsant and anxyolytic activities. Isatin itself is an endogenous oxidized indole with a wide spectrum o...

BACKGROUND & OBJECTIVES Derivatives of isatin are known to have cytotoxicity against human carcinoma cell lines. This compound therefore, has a potential to be used as a chemotherapeutic agent against cancer. This study was done to investigate the antioxidant and anticancer activities of isatin, extracted from flower of a folklore medicinal plant Couroupita guianensis against human promylocytic...

Five isatin anions were prepared by deprotonation of initial isatins in aprotic solvents using basic fluoride and acetate anions (F- and CH₃COO-). The F- basicity is sufficient to deprotonate isatin NH hydrogen from all the studied compounds. This process is reversible. In the presence of proton donor solvents, the anions form the corresponding isatins. The isatin hydrogen acidity depends on th...

Quantitative and qualitative inquiry are sometimes portrayed as distinct and incompatible paradigms for research in education. Approaches to combining qualitative and quantitative research typically " integrate " the two methods by letting them co-exist independently within a single research study. Here we describe intra-sample statistical analysis (ISSA) as a general technique for using quanti...

In the title compound, C(22)H(18)N(2)O, the phenyl and tolyl rings make dihedral angles of 84.71 (7) and 65.11 (6)°, respectively, with the isatin group. The aromatic rings make a dihedral angle of 60.90 (8)°. The imino C=N double bond, exists in an E conformation. In the crystal, mol-ecules are linked by weak π-π stacking inter-actions [centroid-centroid distance = 3.6598 (13) Å].

some new 3-[(5-benzylidene-2-phenyl)-3, 5-dihydro-4-h-imidazol-4-one-3-(4-bezoylhydrazono)]-indole-2-ones (viii) have been synthesized from different isatinhydrazones (ii) by condensing with 2-phenyl-5-benzylidene- 3-n (4-acetyl phenyl)-1, 5-dihydro-imidazol-4-one (vii). their chemical structures have been confirmed by ir, 1hnmr, mass and by elemental analysis. investigation of antimicrobial ac...

NOVEL INHIBITORS OF THE BACTERIAL DE NOVO PURINEBIOSYNTHESIS ENZYMES, N-CARBOXYAMINOIMIDAZOLERIBONUCLEOTIDE SYNTHETASE AND MUTASEbyMARIA V FAWAZAugust 2012 Advisor: Dr. Steven M. FirestineMajor: Pharmaceutical SciencesDegree: Master of ScienceAntibiotic resistance has seen a significant increase during the past decade. Theincreasing frequency of the drug-...

A chemo- and enantioselective cross-aza-benzoin reaction between enals and isatin-derived ketimines is disclosed. The high chemoselectivity (of the acyl anion reaction over enal α- and β-carbon reactions) is enabled by the electronic and steric properties of the N-heterocyclic carbene organocatalyst.

The title compound, C(21)H(21)N(3)O(3), was synthesized by a multi-component 1,3-dipolar cyclo-addition of azomethine ylide, derived from isatin and proline by a deca-rboxylative route, and (E)-1-phenyl-2-nitro-propene. In the mol-ecule, the spiro junction links a planar oxindole ring and a pyrrolidine ring in an envelope conformation. The mol-ecular packing is stabilized by an inter-molecular ...