Isolated hyperferritinemia with normal transferrin saturation and dysmetabolism, in the absence of the two known mutations in the HFE gene of hereditary hemochromatosis Sir, We report on a patient who had isolated hyperfer-ritinemia with normal transferrin saturation, dysme-tabolism, and mild hepatic iron overload. He was negative for the two known mutations in the HFE gene of hereditary hemoch...

Iron deficiency anemia(IDA) is one of the most common nutritional problems in the world.children under 5 years old are considerd as the high risk group consisting a high proportion of IDA patients.in this group,due to the specific conditions,the complication of anemia may lead to serious consequences.this study was designed to determine the prevalence of IDA in 1-5 years old children.A total of...

Hemodialysis patients treated with recombinant human erythropoietin (rhEPO) need adequate iron supplementation to avoid rhEPO hyporesponsiveness due to iron deficiency. Low serum ferritin reflects absolute iron deficiency, whereas normal or high ferritin values in combination with low transferrin saturation (< 20%) indicate functional iron deficiency. In this study, healthy subjects (group I) w...

Vector controlled induction machine drives are increasingly used in industrial drive systems, but the drive performance often degrades with the machine parameter variations. In this paper, a modified vector control system is proposed to achieve decoupling when saturation and iron losses are taking into account. The simulated and experimental results of the modified controller are presented to v...

Iron is essential to erythrocyte oxygen transport and is a catalyst for oxidative metabolism in all cells. Iron is absorbed by the duodenum and requires an acidic environment for optimal absorption. Iron is found for 70% in erythrocytes, and 30% in storage, and a small amount in myoglobin and cytochromes. Iron supplementation reduces anemia in breastfed infants and increases in significant dose...

The link between iron intake as well as body iron stores and coronary heart disease (CHD) has been contentiously debated, and the epidemiologic evidence is inconsistent. We aimed to quantitatively summarize the literature on the association between dietary iron intake/body iron stores and CHD risk by conducting a meta-analysis of prospective cohort studies. PubMed was used to find studies publi...

BACKGROUND There is a marked difference in the degree of expression of the homozygous C282Y HFE genotype that is associated with hereditary hemochromatosis. It has been reported that individuals with the haptoglobin 2-2 type manifest increased iron concentrations, including serum iron, transferrin saturation, and ferritin. METHODS We studied 232 patients, 115 homozygous for the c.845G-->A (C2...

Hereditary hemochromatosis (HHC) is one of the most frequent genetic disorders in humans. In healthy individuals, absorption of iron in the intestine is tightly regulated by cells with the highest iron demand, in particular erythroid precursors. Cloning of intestinal iron transporter proteins provided new insight into mechanisms and regulation of intestinal iron absorption. The aim of this stud...

Hereditary hemochromatosis is inherited in an autosomal recessive manner with partial biochemical expression in heterozygotes. A high percentage of saturation of serum transferrin is the hallmark of the disorder, and serum ferritin concentration gives an approximate estimation of the size of iron stores. Hepatic computed tomography, magnetic susceptometry, and nuclear magnetic resonance provide...

Curcumin is a natural product currently in human clinical trials for a variety of neoplastic, preneoplastic, and inflammatory conditions. We previously observed that, in cultured cells, curcumin exhibits properties of an iron chelator. To test whether the chelator activity of curcumin is sufficient to induce iron deficiency in vivo, mice were placed on diets containing graded concentrations of ...