Grain refinement through severe plastic deformation enables synthesis of ultrahigh-strength nanostructured materials. Two challenges exist in that context: First, deformation-driven grain refinement is limited by dynamic dislocation recovery and crystal coarsening due to capillary driving forces; second, grain boundary sliding and hence softening occur when the grain size approaches several nan...

Iron chelators belonging to three distinct chemical families were assessed in terms of their physicochemical properties and the kinetics of iron chelation in solution and in two biological systems. Several hydroxypyridinones, reversed siderophores, and desferrioxamine derivatives were selected to cover agents with different iron-binding stoichiometry and geometry and a wide range of lipophilici...

Iron plays the central role in oxygen transport by erythrocytes as a constituent of heme and hemoglobin. The importance of iron and heme is also to be found in their regulatory roles during erythroblast maturation. The transcription factor Bach1 may be involved in their regulatory roles since it is deactivated by direct binding of heme. To address whether Bach1 is involved in the responses of e...

Previously, we had identified FOX1 and FTR1 as iron deficiency-inducible components of a high-affinity copper-dependent iron uptake pathway in Chlamydomonas. In this work, we survey the version 3.0 draft genome to identify a ferrireductase, FRE1, and two ZIP family proteins, IRT1 and IRT2, as candidate ferrous transporters based on their increased expression in iron-deficient versus iron-replet...

The present investigation deals with the recovery of iron values from the screw classifier overflow slimes from an iron ore washing plant by means of reverse cationic flotation as an alternate to direct anionic flotation. Selectivity index, an indicator of separation efficiency, was chosen as the response parameter for optimizing the quantity and evaluating a series of generically same but chem...

We assessed the role of the cell labile iron pool in mediating oncogene-induced cell proliferation via repression of ferritin expression. When HEK-293 cells, engineered to inducibly express either active (+) or dominant-negative (-) forms of the H-ras oncogene, were treated with antisense nucleotides to ferritin subunits they displayed (a) decreased ferritin levels, (b) increased labile iron po...

Sludge from a treatment process using iron was exposed to a mildly acidic solution to investigate iron hydroxide's capacity to collect metals from waste. Batches of iron hydroxide were regenerated and reused 50 times to treat both synthetic and real plating waste. Treatment efficiency was very high and steady, and there was no indication of deterioration in any aspect of process performance. Ov...

BACKGROUND Researchers are exploring the effects of adding treatments to the main antimalarial regimens in an attempt to reduce mortality from Plasmodium falciparum. Iron chelation is one potential chemotherapeutic adjuvant treatment. Before advocating adjunctive therapy, the effects of iron chelators in improving patient outcomes need to be examined. OBJECTIVES To assess the effects of iron-...

he cost of sludge disposal can contribute significantly to the cost of product manufacturing. An opportunity exists to eliminate this cost of land disposal of sludge resulting from the zinc phosphate pretreatment process. In addition, the cost of the phosphating process may be reduced by reclaiming this sludge to a zinc-phosphate replenishment solution and other useful products. For those not f...

Background Double inversion recovery (DIR) is the most commonly used black blood (BB) preparation method. However its single slice nature makes the acquisition inefficient and flow-dependence causes insufficient blood suppression when stagnant blood or in-plane blood flow is present. In this work, we propose to use ferumoxytol, an FDA approved iron oxide particle for treating iron deficiency an...