Iron imbalance/accumulation has been implicated in oxidative injury associated with many degenerative diseases such as hereditary hemochromatosis, beta-thalassemia, and Friedreich's ataxia. Mitochondria are particularly sensitive to iron-induced oxidative stress - high loads of iron cause extensive lipid peroxidation and membrane permeabilization in isolated mitochondria. Here we detected and c...

Two biomimetic iron(II)-catecholate complexes, [(Tp)Fe(CatH)] (1) and [(Tp)Fe(DBCH)] (2) (where Tp = hydrotris(3,5-diphenylpyrazole-1-yl)borate, CatH = monoanionic pyrocatecholate and DBCH = monoanionic 3,5-di-tertbutyl catecholate), have been isolated and characterized to study their reactivity towards dioxygen. The single-crystal X-ray structure of (1) reveals a high-spin iron(II) center liga...

Mutation of a serine that forms a hydrogen bond to the iron-sulfur cluster of the Rieske iron-sulfur protein to a cysteine results in a respiratory-deficient yeast strain due to formation of iron-sulfur protein lacking the iron-sulfur cluster. The Rieske apoprotein lacking the iron-sulfur cluster is inserted into both monomers of the dimeric cytochrome bc(1) complex and processed to mature size...

Gravimetric, titrimetric, polarographic, optical and radiochemical methods have been reported for the determination of iron(II) and (III). Numerous reagents have also been reported for the spectrophotometric determination of Fe(II); for example, thiocyanate, dipyridine, tripyridine and 1,10-phenanthroline. The 1,10phenanthroline family has been extended to the use of dihydroxy, dimethyl, nitro ...

Ribonucleotide reductase is the rate limiting enzyme of deoxynucleoside triphosphate synthesis and is considered to be an excellent target of cancer chemotherapy. Trimidox, a newly synthesized compound, inhibits this enzyme and has in vitro and in vivo antitumour activity. As trimidox was able to upregulate the expression of the transferrin receptor in HL-60 human promyelocytic leukaemia cells,...

Intravenous iron therapy is a useful treatment for the rapid correction of iron deficiency anaemia and can be used to avoid or reduce the requirement for allogeneic blood transfusion. Several intravenous iron preparations are available commercially which differ in cost, mode of administration and side effect profile. There are few data directly comparing the efficacy of these preparations. In t...

BACKGROUND Dinitrosyl nonheme-iron complexes can appear in cells and tissues overproducing nitric oxide. It is believed that due to their chemical nature these species may be implicated in certain pathophysiological events. We studied the possible role of low molecular mass dinitrosyl iron complexes in the control of noradrenaline release in electrically stimulated rat tail artery. RESULTS A ...

Pseudomonas aeruginosa produces a blue pigment called pyocyanin. In the presence of oxidizable substrates, bacteria reduce this pigment to a colorless product, leukopyocyanin. Pyocyanin can also be nonenzymatically reduced by NADH. Leukopyocyanin formed by cell- or NADH-mediated reduction nonenzymatically reduces oxygen or Fe(III). Pyocyanin-dependent iron reduction by whole bacterial cells was...

The alkylation of complexes 2 and 7 with Grignard reagents containing β-hydrogen atoms is a process of considerable relevance for the understanding of C-H activation as well as C-C bond formation mediated by low-valent iron species. Specifically, reaction of 2 with EtMgBr under an ethylene atmosphere affords the bis-ethylene complex 1 which is an active precatalyst for prototype [2+2+2] cycload...

to understand the rate of oxidation of sponge irons and its mechanisim, their physical and chemical properties are normally required. in this report attempt has been made to show the results of research on varius pellets and briqutts produced at ahwaz steel complex. in presenting these data, the rate of oxidation of these articles in air between 300 and 600 °c is also quotted and analysed. in a...