sis usually involve chaotropic agents such as guanidinium chloride and (or) detergents for the dissociation of iron at an acidic pH from transferrin. Reduction is achieved with various reducing compounds such as ascorbic acid, hydroxylamine, thioglycolic acid, and others. Among these, ascorbic acid is unique in its property not only to reduce but also to chelate iron. This property appears to b...

This indirect method for determination of desferrioxamine (DFO, deferoxamine, Desferal) and its chelated compounds ferrioxamine (FO) and aluminoxamine (AIO) in biological fluids involves metal chelate formation and solvent extraction, the metal being determined by Zeeman atomic absorption spectrometry (Zeeman-AAS). Special attention was paid to the pH and recovery of extraction, iron-aluminum i...

The protective effects of selected members from a series of caffeic acid esters and flavonoids were tested in various toxicity paradigms using U937 cells, previously shown to be sensitive to either iron chelators or bona fide radical scavengers or to both classes of compounds. It was found that all the protective polyphenols were active at very low concentrations and that their effects were obs...

production of high quality with high shelf life of apple fruits, is of great importance. present study investigates the effects of ammonium nitrate and iron on quality and antioxidant properties of apple fruit cultivar gala in a randomized complete block design. foliar application of iron chelate in three levels (0, 5 and 10 mg/l) and soil nutrition of ammonium nitrate in three levels as strip ...

Desferrioxamine, widely used for the treatment of iron overload in Cooley's anaemia, binds iron so tightly that it should quantitatively remove iron from transferrin. Studies conducted in vivo and in vitro, however, have failed to demonstrate significant depletion of transferrin-bound iron by a stoichiometric excess of desferrioxamine. However, low molecular weight chelating agents, capable of ...