نتایج جستجو برای: ip and rs
تعداد نتایج: 16837129 فیلتر نتایج به سال:
BACKGROUND Quantitative computed tomography (CT) analysis has been proposed as a means of objectively assessing fibrotic interstitial pneumonia (IP) including idiopathic pulmonary fibrosis (IPF). We investigated whether percentages of high-attenuation areas (HAA%) and cystic areas (CA%) quantified from CT images were useful as indices of fibrotic IP. METHODS CT images of 74 patients with fibr...
In pancreatic acinar cells, agonists evoke intracellular Ca(2+) transients which are initiated in the apical region of these polarized cells. There are contradictory experimental data concerning Ca(2+) release from ryanodine receptors (RyRs) in the apical region. In the present study, we have used low doses of ryanodine to open RyRs leading to the release of Ca(2+) from intracellular stores. Ry...
Intracellular Ca(2+) release is a versatile second messenger system. It is modeled here by reaction-diffusion equations for the free Ca(2+) and Ca(2+) buffers, with spatially discrete clusters of stochastic IP(3) receptor channels (IP(3)Rs) controlling the release of Ca(2+) from the endoplasmic reticulum. IP(3)Rs are activated by a small rise of the cytosolic Ca(2+) concentration and inhibited ...
There is a glaring lack of knowledge on mouse colonic motility in vivo, primarily due to unavailability of adequate recording methods. Using a noninvasive miniature catheter pressure transducer inserted into the distal colon, we assessed changes in colonic motility in conscious mice induced by various acute or chronic stressors and determined the neurotransmitters mediating these changes. Mice ...
introduction the mahour exploration area is a polymetallic system containing copper, zinc and silver. the mineralization can be seen in two forms of veins and disseminations. this area is structurally within the lut block, west of deh-salm village. recent exploration work and studies carried out by geologists on this volcanic-plutonic area of lut demonstate its importance indicating new reserve...
وارون‌سازی داده‌های ژئوفیزیکی نقش مهمی در بررسی‌های زمین‌شناسی ایفا می‌کند. در محدوده معدنی درح داده‌های ژئوفیزیکی تصحیح‌شده مغناطیسی، مقاومت ویژه و قطبیدگی القایی، برای به‌دست آوردن شکل و دیگر پارامتر‌های توده‌های زیر‌سطحی مدل شده‌اند. بدین‌منظور داده‌های مغناطیسی ابتدا فیلتر و سپس به روش وارون‌سازی فشرده داده‌های مغناطیسی مدل‌سازی شدند. این روش وارون‌سازی، براساس اصول ابتدایی کمینه‌سازی سط...
We tested the hypothesis that vasomotor control is differentially regulated between feed arteries and downstream arterioles from the cremaster muscle of C57BL/6 mice. In isolated pressurized arteries, confocal Ca(2+) imaging of smooth muscle cells (SMCs) revealed Ca(2+) sparks and Ca(2+) waves. Ryanodine receptor (RyR) antagonists (ryanodine and tetracaine) inhibited both sparks and waves but i...
We report the first biochemical and functional characterization of inositol trisphosphate receptors (IP(3)Rs) and ryanodine receptors (RyRs) in the nuclear membrane of bone-forming (MC3T3-E1) osteoblasts. Intact nuclei fluoresced intensely with anti-RyR (Ab(34)) and anti-IP(3)R (Ab(40)) antisera in a typically peripheral nuclear membrane pattern. Isolated nuclear membranes were next subjected t...
Receptor signaling at the plasma membrane often releases calcium from intracellular stores. For example, inositol triphosphate (IP3) produced by receptor-coupled phospholipase C activates an intracellular store calcium channel, the IP(3)R. Conversely, stores can induce extracellular calcium to enter the cell through plasma membrane channels, too. How this "reverse" coupling works was unclear, b...
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