We previously reported that methoxyamine (an inhibitor of base excision repair) potentiates iododeoxyuridine (IUdR)-induced radiosensitization in human tumor cells. In this study, we investigated the potential mechanisms of this enhanced cell death. Human colorectal carcinoma RKO cells were exposed to IUdR (3 micromol/L) and/or methoxyamine (3 mmol/L) for 48 hours before ionizing radiation (5 G...

Nuclear medicine uses ionizing radiation for both in vivo diagnosis and therapy. Ionizing radiation comes from a variety of sources, including x-rays, beam therapy, brachytherapy, and various injected radionuclides. Although PET and SPECT remain clinical mainstays, optical readouts of ionizing radiation offer numerous benefits and complement these standard techniques. Furthermore, for ionizing ...

Knowing the amount of ionizing photons from young star-forming galaxies is of particular importance to understanding the reionization process. Here we report initial results of Subaru/Suprime-Cam deep imaging observation with a special narrow-band filter to optimally trace ionizing radiation from galaxies at z > 3. The unique wide field-of-view of Suprime-Cam enabled us to search for ionizing p...

Evidence of health benefits and longer average life-span following low-dose irradiation should replace fear, “all radiation is harmful,” and “the perception of harm” as the basis for action in the 21 century. Hormesis is the excitation, or stimulation, by small doses of any agent in any system. Large doses inhibit. “Low dose” is defined as any dose between ambient levels of radiation and the th...

Gholami M1, Abedini MR2, Khossravi HR3, Akbari S4 1. Instructor, Department of medical physics, Faculty of medicine, Lorestan University of medical sciences 2. Assistant professor, Department of radiology, Faculty of medicine, Lorestan University of medical sciences 3. Assistant professor, Department of radiation protection, Iranian Atomic Energy Organization 4. Assistant professor, D...

In response to ionizing radiation, p53 plays a critical role in regulating DNA repair and apoptosis. Among multiple phosphorylation sites, evidence suggests that Ser46 promotes apoptotic cell death through mitochondrial outer membrane permeabilization (MOMP) and subsequent activation of the caspase 7-PARP pathway. Therefore, we investigated which phosphatase regulates Ser46 after ionizing radia...