The use of the renewable platform molecule 5-hydroxymethylfurfural (5-HMF) in multi-component reaction with a diamine and an alkynone to generate seven-membered 1,5-benzodiazepines is described. Due sensitivity 5-HMF strong acidic basic conditions, investigation required in-depth revisit parameters as compared benchmark aldehydes. Among catalysts/solvents couples, ammonium acetate ethanol prove...