The conversion of physical signals, such as contractile forces or external mechanical perturbations, into chemical signaling events is a fundamental cellular process that occurs at cell-extracellular matrix contacts, known as focal adhesions. At these sites, transmembrane integrin receptors are associated via their cytoplasmic domains with the actin cytoskeleton. This interaction with actin is ...

Microtubules switch between growing and shrinking states, a feature known as dynamic instability. The biochemical parameters underlying dynamic instability are modulated by a wide variety of microtubule-associated proteins that enable the strict control of microtubule dynamics in cells. The forces generated by controlled growth and shrinkage of microtubules drive a large range of processes, inc...

Consider a complex system whose macrostate is statistically observable, but yet whose operating mechanism is an unknown black-box. In this paper we address the problem of inferring, from the system’s macrostate statistics, the system’s intrinsic force yielding the observed statistics. The inference is established via two diametrically opposite approaches which result in the very same intrinsic ...

The constraints of the speech production apparatus imply that our vocalizations are approximately restricted to a lowdimensional manifold embedded in a high-dimensional space. Manifold learning algorithms provide a means to recover the approximate embedding from untranscribed data and enable use of the manifold’s intrinsic distance metric to characterize acoustic similarity for downstream autom...

This study examines the various conflicting issues between and among public service agencies to enhance Nigeria's effective security delivery. While embraces use of a systems approach, it adopts conceptual review approach with pictorial evidence critical extant literature discuss intra- inter-sectional conflict in Nigerian delivery system. The findings show, that superior complexities personnel...

background: motivation is a driver to health worker performance in most ghanaian hospitals. in view of this, ghana’s ministry of health has rolled out enough motivational policies to accentuate work performance of health workers. objective: the focus of this study was to examine the impact of motivation and identify how intrinsic and extrinsic motivating factors affect the work performance of h...

In this talk we will describe the problems that one encounters when one tries to connect string theory with particle phenomenology. Then, in order to have chiral matter describing quarks and leptons, we introduce the magnetized D branes. Finally, as an explicit example of a string extension of the Standard Model, we will describe the one constructed by Ibáñez, Marchesano and Rabadán. Work parti...

Canadian Armed Forces (CAF) Food Services recently implemented a standardized menu at all static service locations. Within this new regime, CAF Food Services requires a standard against which they can measure labour performance and use to inform future rationalization of staffing. To start, a pilot study was conducted in February and March 2015 to collect labour performance data. In this paper,...

The accelerating expansion of the universe suggests that an unknown component with strongly negative pressure, called dark energy, currently dominates the dynamics of the universe. Such a component makes up ;70% of the energy density of the universe yet has not been predicted by the standard model of particle physics. The best method for exploring the nature of this dark energy is to map the re...