BACKGROUND AND PURPOSE The effect of postoperative intra-articular bolus injections after total hip arthroplasty (THA) remains unclear. We tested the hypothesis that intra-articular bolus injections administered every 6 hours after surgery during the first 24 hours would significantly improve analgesia after THA. PATIENTS AND METHODS 80 patients undergoing THA received high-volume local infil...

Interventions: Patients were randomized to receive 2.5μg/kg (ITM-2.5) or 5μg/kg (ITM-5) intrathecal morphine or sham-control preoperatively. Anaesthesia was induced and maintained with sufentanil (limited to 1μg/kg), propofol, rocuronium and isoflurane. Blinded observer-caregivers extubated the patients using protocol-defined criteria, and on-demand intravenous morphine (IVM) was administered t...

PURPOSE To determine whether continuous infiltration of local anaesthetic can reduce the pain score and morphine use over 48 hours after total knee arthroplasty (TKA). METHODS 11 men and 43 women aged 50 to 82 years who underwent unilateral TKA for osteoarthritis were recruited. They were randomised into 3 groups. In group 1, 17 patients who acted as controls received patient-controlled analg...

Procedural pain in the neonatal intensive care unit triggers a cascade of physiological, behavioral and hormonal disruptions which may contribute to altered neurodevelopment in infants born very preterm, who undergo prolonged hospitalization at a time of physiological immaturity and rapid brain development. The aim of this study was to examine relationships between cumulative procedural pain (n...

background: there are numerous investigations on wide range of issues that disrupt regulatory spermatogenesis, individuals who are exposed to drug abuse faced infertility and immature spermatogenesis. objective: the aim of this study was to evaluate the addiction effects of morphine and its derivatives on rats spermatogenesis. materials and methods: 40 male wistar rats were randomly divided int...

Pain is one of the most distressing post-operative consequences of surgeries. Opioids have been the mainstay in providing pain relief. Morphine is the considered to be the “gold standard” amongst opioids as an analgesic. Nalbuphine, a synthetic opioid agonist/antagonist has analgesic potency almost equivalent to that of morphine on a milligram basis and fewer complications like respiratory depr...

This study examined the effect of morphine on oral infection with virulent Salmonella typhimurium. Animals were treated with a 75-mg slow-release morphine pellet followed by inoculation with salmonellae. Morphine markedly sensitized mice to oral infection, as assessed by survival, mean survival time, and colony culture. By 24 h after Salmonella inoculation, morphine-treated mice had a 105-fold ...

Background & objective: Traditionally, analgesia after heart surgery is obtained with the use of intravenous opioids (particularly morphine). Continuous infusion narcotic analgesics results in a more constant level analgesia, but slow accumulation may cause excessive sedation. The caudal epidural narcotics, alone or local anesthetics have been advocated following lower abdominal and thoraci...

AIM To examine the cardiovascular effects of an intravenous bolus of morphine, 100 microg/kg, in 17 ventilated preterm infants. METHODS Heart rate and blood pressure were monitored. Right ventricular output, superior vena caval flow, and the width of the ductus arteriosus were measured by Doppler echocardiography 10 and 60 minutes after the morphine injection, and the values compared with bas...

Male rats made diabetic by intravenous injection of streptozotocin were used to evaluate the effect of the diabetic state on morphine- and nalmefene-induced changes in food intake and body weight. Morphine increased 4 hour food intake in non-diabetic rats after an initial injection, but increased intake in diabetic rats only after repeated injections. Unlike short term measurements, morphine de...