The delivery of drugs into systemic circulation via skin has generated much attention during the last decade. Transdermal therapeutic systems propound controlled release of active ingredients through the skin and into the systemic circulation in a predictive manner. Drugs administered through these systems escape first-pass metabolism and maintain a steady state scenario similar to a continuous...

Sexually dimorphic growth hormone (GH) secretory pattern is important in the determination of gender-specific patterns of growth and metabolism in rats. Whether GH secretion in humans is also sexually dimorphic and the neuroendocrine mechanisms governing this potential difference are not fully established. We have compared pulsatile GH secretion profiles in young men and women in the baseline s...

Emergency standard open tracheostomy is performed in impending or actual cardiac and respiratory-cardiac arrest. Indications are rare, but the procedure must be safe and rapidly effective. Neither facilitating (but risky) neck manipulations nor electrocautery are required nor, because of the urgency to obtain airway ingress, are bilateral traction stitches applied. No intravenous line should be...

Interferon has been shown to have an antiproliferative effect on leukaemic blast cells in vitro [ l , 3, 41. In short-term liquid culture, 50% inhibition of growth is achieved at IFN-a concentrations of 103 units/ml using myeloblasts derived from patients with acute myelogenous leukaemia (AML) [5]. Pharmacokinetic studies in patients receiving IFN-a by continuous intravenous infusion (i.v.i) ha...

5-Fluorouracil (5-FU) is a key anticancer drug that for its broad antitumor activity, as well as for its synergism with other anticancer drugs, has been used to treat various types of malignancies. In chemotherapeutic regimens, 5-FU has been combined with oxaliplatin, irinotecan and other drugs as a continuous intravenous infusion. Recent clinical chemotherapy studies have shown that several of...

Materials and Methods: One hundred and seventeen boys who were in the age range of 6 months to 6 years and referred for hypospadiasis repair to our referral teaching hospital were included in this randomized clinical trial. Patients were randomly assigned to one of the two study groups before anesthesia induction. Anesthesia was maintained with a continuous intravenous infusion of propofol and ...

Peripheral intravenous therapy is frequently used in routine hospital practice and, due to various factors, its most common side effect is phlebitis. The infusion of vancomycin is particularly associated with phlebitis despite its widespread use. French guidelines recommend central intravenous infusion for high concentrations of vancomycin, but peripheral intravenous therapy is often preferred ...