BACKGROUND The administration of opioids before induction of general anesthesia can be considered as a problem in cesarean section. The aim of this study was to compare the effects of intravenous Fentanyl as a premedication before induction of general anesthesia versus placebo on maternal hemodynamic parameters and on the first and fifth minutes Apgar score in the neonates in elective cesarean ...

Anaesthesia was induced with midazolam 1 mg, fentanyl 2 μg/kg and propofol 2 mg/kg intravenously. Vecuronium bromide 0.1 mg/kg intravenously was used for muscle relaxation followed by endotracheal intubation. Anaesthesia was maintained with 1-2% sevoflurane in 50% O2 and N2O gas mixture. Intraoperative analgesia was provided with incremental doses of intravenous fentanyl 1 μg/kg and muscle rela...

Following aortic valve replacement in a patient with aortic stenosis and cardiac failure, marked pulsus alternans recurred immediately after intravenous injection of 0.5 mg fentanyl, without concomitant changes in heart rate, mean left atrial pressure, or the electrocardiogram. Pulsus alternans is known to occur in association with heart failure and aortic stenosis, but has not been reported pr...

OBJECTIVE The objectives of the study were to determine the absolute bioavailability of fentanyl from fentanyl buccal soluble film, estimate the percentage of a fentanyl dose absorbed through the buccal mucosa, and compare the bioavailability of equivalent doses administered either as single or multiple dose units. DESIGN Open-label, randomized, four-period, Latin-square crossover pharmacokin...

While opioid abuse is an established medical and public health issue, the increased availability of highly potent synthetic opioids, such as fentanyl, has given rise to acute health complications, including a comatose state and death during drug overdose. Since respiratory depression that leads to acute hypoxia is the most dangerous complication of opioid drug use, we examined the effects of in...

PURPOSE The aim of this prospective, double-blind, randomized study was to investigate the analgesic effects of low-dose ketamine on intravenous patient-controlled analgesia (IV-PCA) with fentanyl for pain control in pediatric patients following the Nuss procedure for pectus excavatum. MATERIALS AND METHODS Sixty pediatric patients undergoing the Nuss procedure were randomly assigned to recei...

BACKGROUND Patients with proximal femoral neck fracture have a high short-term mortality, a high risk of postoperative complications, and impaired quality of life. One of the challenges related to the prehospital treatment of these patients is to administer systemic opioids fast and properly. Effective analgesic prehospital treatment ought be initiated rapidly in order to alleviate the stress t...

Background: Direct laryngoscopy and endotracheal intubation elicit hemodynamic pressor responses which may be hazardous in high risk patients. Fentanyl, a low cost synthetic opioid, when used judiciously, good option to attenuate this stress response. Aims Objectives: The present study has been conducted compare the efficacy of three different doses intravenous fentanyl attenuation response ele...

Patients with severe, painful injuries and illnesses treated in the emergency department are commonly administered opioid medications. Intravenous administration provides the most rapid onset of pain relief and is readily titrated. Fentanyl, administered intravenously, is well documented as an effective medication for pain management in the emergency department. It is preferred in many settings...

BACKGROUND It has been suggested that oxycodone is effective in relieving acute postoperative pain. The aim of this study was to investigate the efficacy and tolerability of oxycodone (O) versus fentanyl (F), and the adequate potency ratio of oxycodone and fentanyl in patients with intravenous patient-controlled analgesia after gastric laparotomy. METHODS In this double-blinded, randomized, c...