BACKGROUND Although pregabalin therapy is beneficial for neuropathic pain (NeP) by targeting the CaVα2δ-1 subunit, its site of action is uncertain. Direct targeting of the central nervous system may be beneficial for the avoidance of systemic side effects. RESULTS We used intranasal, intrathecal, and near-nerve chamber forms of delivery of varying concentrations of pregabalin or saline delive...

s: 7. Papisov M, Belov V, Fischman A, Titus J, Gillooly C, Gagne M. PET imaging of macromolecule and particle delivery to the brain through intrathecal administration in rodents and non-human primates. 2012 SNM Annual Meeting, Miami, Fl.

Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silencing or upregulation in the central nervous system has been limited by the inability to provide more than limited deep parenchymal expression in adult animals using delivery routes with the most clinical relevance (intravenous or intrathecal). Here, we demonstrate that the spinal pia membrane repre...

Despite recent insights into the pathobiology underlying central nervous system (CNS) malignant gliomas (MGs) and the development of new putative therapeutic compounds to treat these neoplasms, there remains no curative surgical or medical treatment for these tumors. Extensive surgical resection has been shown to prolong survival but is not a total cure because of widespread infiltrative micros...

Background: Adding morphine as adjuvant intrathecal drug for cesarean section is a gold standard for post-operative analgesia according to literature, but because of frequent incidence of nausea, vomiting and pruritus, it has limited popularity. Various mechanisms have been demonstrated for the opioid-induced pruritus, with a variety of medications with different mechanisms of actions for preve...

BACKGROUND It has been suggested that morbidly obese parturients may require less local anesthetic for spinal anesthesia. The aim of this study was to determine the effective dose (ED(50)/ED(95)) of intrathecal bupivacaine for cesarean delivery in morbidly obese patients. METHODS Morbidly obese parturients (body mass index equal to or more than 40) undergoing elective cesarean delivery were e...

218 Ultrasound Guided Epidural Analgesia for Labour in a Patient with an Intrathecal Baclofen Pump Abstract Type: Case Report/Case Series Manasi Badve, M.D.; Tanmay Shah, M.D.; Jeremy Rice, D.O.; Manuel Vallejo, M.D. Magee-Womens Hospital of UPMCType: Case Report/Case Series Manasi Badve, M.D.; Tanmay Shah, M.D.; Jeremy Rice, D.O.; Manuel Vallejo, M.D. Magee-Womens Hospital of UPMC Intrathecal ...

BACKGROUND The neuroprotective role of minocycline in the treatment of brachial plexus injury is controversial. OBJECTIVE To study the neuroprotective effect of minocycline via different routes in adult Sprague Dawley rats with brachial plexus injury. METHODS The C7 nerve roots of the animals were avulsed via an anterior extravertebral approach. Traction force was used to transect the ventr...

PURPOSE The phosphodiesterase 5 inhibitor sildenafil has antinociceptive effects, mediated by an increase in cGMP. This study examined the role of spinal adenosine and serotonin receptors played in the antinociceptive effects of intrathecal sildenafil. MATERIALS AND METHODS Intrathecal catheters were inserted into the subarachnoid space of Sprague-Dawley male rats as a drug delivery device. P...

OBJECTIVE Up to 90% of patients with advanced cancer experience intractable pain. For these patients, oral analgesics are the mainstay of therapy, often augmented with intrathecal drug delivery. Neurosurgical ablative procedures have become less commonly used, though their efficacy has been well-established. Unfortunately, little is known about the safety of ablation in the context of previous ...