OBJECTIVE To evaluate the role of intrapleural streptokinase in the management of complicated parapneumonic effusions in children. DESIGN Prospective comparative study. SETTING Cheng Kung University Hospital, a tertiary medical center in Tainan, Taiwan. PATIENTS AND METHODS We enrolled as our prospective study group 20 consecutive children with complicated parapneumonic effusions who rece...

BACKGROUND Limitations in physicians' knowledge regarding fibrinolytic therapy for acute ischemic stroke may contribute to low rate of fibrinolytic therapy in China. Here physicians' knowledge was surveyed on intravenous fibrinolytic therapy for acute ischemic stroke. METHODS Neurologists (n = 175) from 27 major general hospitals in Shanxi province, P. R. China, were invited to complete quest...

OBJECTIVES We sought to best estimate the benefits and risks associated with rescue percutaneous coronary intervention (PCI) and repeat fibrinolytic therapy as compared with conservative management in patients with failed fibrinolytic therapy for ST-segment myocardial infarction (STEMI). BACKGROUND Fibrinolytic therapy is the most common treatment for STEMI; however, the best therapy in patie...

For the future treatment of ST-elevation myocardial infarction, fibrinolytic therapy will be the most widely used therapy, because of its simplicity, worldwide availability and relatively low cost. In comparison to primary angioplasty, which will continuously be hampered by its limited availability and inherent time delay, fibrinolytic therapy has two major drawbacks: partial efficacy and a sma...

background: streptokinase is a bacterial protein produced by different beta hemolytic streptococci and widely used in thrombolytic treatment. the main disadvantage of using streptokinase is antibody formation which causes allergic reaction to neutralize effects of streptokinase therapy. aim of this study was investigate of recombinant mutant streptokinase fibrinolytic activity. m aterials and m...

The activity of endogenous colony-stimulating factor (CSF) in malignant pleural effusions of lung cancer patients before and during daily intrapleural infusions of recombinant interleukin-2 (IL-2) was measured quantitatively by colony-forming bioassay and radioimmunoassay (RIA). Before therapy, malignant pleural effusions had various levels of CSF activities, and this CSF activity was neutraliz...

BACKGROUND We performed this observational prospective study to evaluate the results of the application of a diagnostic and therapeutic algorithm for complicated parapneumonic pleural effusion (CPPE) and pleural parapneumonic empyema (PPE). MATERIAL/METHODS From 2001 to 2007, 210 patients with CPPE and PPE were confirmed through thoracocentesis and treated with pleural drainage tubes (PD), fi...

TOPIC: Disorders of the Pleura TYPE: Medical Student/Resident Case Reports INTRODUCTION: Intrapleural fibrinolytic therapy is a common, surgery-avoiding option in treatment complicated para-pneumonic effusion. It has been shown to be safe majority patients, with most significant risk being severe pleural hemorrhage. In this case report, we will present unique patient who developed concurrent ma...