We read with interest the Article by Mikael Mazighi and colleagues,1Mazighi M Richard S Lapergue B et al.Safety efficacy of intensive bloaod pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP-TARGET): a multicentre, open-label, randomised controlled trial.Lancet Neurol. 2021; 20: 265-274Summary Full Text PDF PubMed Scopus (20) Google Scholar who tested whether...

BACKGROUND Onchocerciasis has been implicated in the pathogenesis of epilepsy. The debate on a potential causal relationship between Onchocerca volvulus and epilepsy has taken a new direction in the light of the most recent epidemic of nodding syndrome. OBJECTIVE To document MRI changes in people with different types of epilepsy and investigate whether there is an association with O. volvulus...

No large-scale, longitudinal studies have examined the combined effects of blood pressure (BP) and total cholesterol levels on long-term risks for subtypes of cardiovascular death in an Asian population. To investigate these relationships, a meta-analysis of individual participant data, which included 73 916 Japanese subjects (age, 57.7 years; men, 41.1%) from 11 cohorts, was conducted. During ...

We present a magnetic resonance imaging of a 38 old woman, admitted with clinical symptoms of expansive cerebellar lesion. No mural nodule and no enhancement after gadolinium injection were noted. She was operated upon and an anatomico-pathological diagnosis of a simple cyst was made. Cysts of the posterior fossa are common in the literature, but the simple cyst is rare. Considered in the diffe...

Cerebral necrosis after radiation therapy of extracranial neoplasms is an infrequent but well-documented complication [1-5]. CT and MR findings associated with changes caused by radiation therapy have been reported; however, differentiating changes caused by irradiation from postoperative changes and recurrent tumor may not always be possible because the·CT and MR findings are nonspecific [6-8]...

Stroke remains one of the most promising targets for cell therapy. Thorough preclinical efficacy testing of human neural stem cell (hNSC) lines in a rat model of stroke (transient middle cerebral artery occlusion) is, however, required for translation into a clinical setting. Magnetic resonance imaging (MRI) here confirmed stroke damage and allowed the targeted injection of 450,000 hNSCs (CTX0E...

Background and Purpose—Hemorrhagic transformation is frequently seen on CT scans obtained in the subacute phase of ischemic stroke. Its prognostic value is controversial. Methods—We analyzed 554 patients with acute ischemic stroke enrolled in the Multicenter Acute Stroke Trial–Italy (MAST-I) study in whom a second CT scan was performed on day 5. Presence of 1) intraparenchymal hemorrhages (hema...

BACKGROUND Alcoholic steatohepatitis (ASH) is a serious complication of alcoholic liver disease. The diagnosis of ASH requires the association of steatosis, evidence of hepatocellular injury with ballooning degeneration, and polynuclear neutrophil infiltration on liver biopsy. Whether these lesions, in addition to other histological features observed in liver tissue specimens, have prognostic s...