Maintenance of long term culture and conventional xenografting of early B-lineage acute lymphoblastic leukemia cells is most difficult. Matrigel, a solubilized attachment matrix shown to aid growth of anchorage dependent solid tumors, was studied in heterotransplantation. Material for xenografting was derived from 5 patient bone marrow aspirates and 5 cell lines previously established and maint...

OBJECTIVES To investigate the possible role of cystatin C in eye biological fluids locally and in serum and lactoferrin revealing anti-tumor activity in eye tumor development. BACKGROUND The increased number of eye tumors was registered recently not only in the countries with high insolation, but also in the northern countries including Russia (11 cases per million of population). Search for ...

PURPOSE To evaluate and compare the attitudes of ophthalmologists and gynecologists in suggesting appropriate approach to pregnancy in different ocular conditions. METHODS Specialty-specific questionnaires on delivery mode and abortion indications for ophthalmic patients (refractive, vascular, oncologic, retinal, glaucoma, postoperation, posttrauma, and infectious) were designed and distribut...

PURPOSE To investigate dosimetric differences among several clinical treatment planning systems (TPS) and Monte Carlo (MC) codes for brachytherapy of intraocular tumors using 125I or 103Pd plaques, and to evaluate the impact on the prescription dose of the adoption of MC codes and certain versions of a TPS (Plaque Simulator with optional modules). METHODS Three clinical brachytherapy TPS capa...

PURPOSE Since deterioration of the immune apparatus is closely associated with cancer, we examined the effect of aging on the growth and metastasis of intraocular melanomas in mice. METHODS Murine B16LS9 melanoma cells were transplanted into the posterior compartment of the eye (vitreous chamber) and intraocular tumor growth and development of liver metastases were evaluated in young (8-10 we...

The purpose of this study is to examine the capability of photoacoustic (PA) imaging (PAI) in assessing the unique molecular and architectural features in ocular tumors. A real-time PA and ultrasonography (US) parallel imaging system based on a research US platform was developed to examine retinoblastoma in mice in vivo and human retinoblastoma and uveal melanoma ex vivo. PA signals were genera...

purpose: to describe the biometric changes and their effect on intraocular lens (iol) power calculation after trabeculectomy and to compare the accuracy of four formulas namely srk/ii, srk/t, holladay and hoffer q for iol power calculation in these patients. methods: thirty-four eyes of 31 glaucoma patients who were scheduled for primary trabeculectomy were enrolled. a non-contact biometry devi...

Neovascular glaucoma is caused by tissue hypoxia, especially secondary to posterior segment diseases. Angiogenic factors precipitate neovascularization in trabecular meshwork. Due to this, aqueus outflow is obtructed and intraocular pressure is increased. The most common reasons of neovascular glaucoma are diabetic retinopathy, central retinal vein occlusion and ocular ischemic syndrome. Anothe...