Sneddon's syndrome (SS) is a rarely seen thrombotic vasculopathy characterized by the combination of ischemic cerebrovascular disease with livedo racemose (LR) and mainly affects young women in third decade life. We present case an 32 year old diagnosed SS 17 years ago, admitted to our emergency department when she was 37 weeks pregnant, as having superimposed severe preeclampsia intrahepatic c...

OBJECTIVE To determine the frequency of patients with dermatoses in the third trimester of pregnancy and to identify various clinical types of dermatoses in the third trimester. METHODS The study was carried out at the Department of Dermatology and the Department of Gynaecology & Obstetrics, PNS Shifa Hospital, Karachi, from January 2 to July 1, 2008. Two hundred pregnant women in their third...

BACKGROUND Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-associated liver disease of unknown etiology. The aim of this study was to investigate the change in maternal and fetal adrenal function in clinical and experimental ICP. MATERIAL/METHODS The maternal and fetal serum levels of cortisol and dehydroepiandrosterone sulfate (DHEAS) were determined in 14 women with ICP and in pr...

Intrahepatic pregnancy cholestasis (ICP) is associated with increased fetal complications. It linked to an risk. Early diagnosis of this disease reduces these In study, it was aimed determine the sensitivity and specificity biochemical tests according cut off values. The values 14 patients bile acid ≥40 μmol / L diagnosed intrahepatic 40 <40 were compared retrospectively 60 control patients....

................................................................................................... 8 INTRODUCTION ......................................................................................... 9 REVIEW OF THE LITERATURE ................................................................. 10 1. Physiology of bile acids .......................................................................

UNLABELLED  Background and aims. Patients with intrahepatic cholestasis of pregnancy (ICP) benefit from ursodeoxycholic acid (UDCA) treatment. Since there is still certain reluctance to use UDCA in pregnant women, mainly due to warnings in the official SPC information in respective drug leaflets, our objective was to assess the efficacy and safety of UDCA during pregnancy. MATERIAL AND METHOD...

PURPOSE The goal of this study was the early diagnosis of ABCB11 spectrum liver disorders, especially those focused on benign recurrent intrahepatic cholestasis and progressive familial intrahepatic cholestasis. METHODS Fifty patients presenting neonatal cholestasis were evaluated to identify underlying etiologies. Genetic analysis was performed on patients suspected to have syndromic disease...

Thus, the changes in maternal steroid metabolism caused by cholestasis are reflected in the steroid profile of the fetoplacental circulation. Furthermore, maternal intrahepatic cholestasis may result in the production of some substance which crosses the placenta and affects fetal steroid metabolism. Received for publication 7 November 1973 and in revised form 13 February 1974. INTRODUCTION Intr...

Introduction: Cholestasis of pregnancy usually presents with pruritus in the third trimester and it has good maternal prognosis. However, severe cholestasis can have a significant impact on the fetus leading to intrauterine death. Case Report: A 28-year-old female had severe cholestasis of pregnancy in first pregnancy, in second she developed pruritus and cholestatic liver function tests at 17 ...