Spine is the most essential part of human body. Vertebrae and intervertebral discs are important parts of Spine. The Inter vertebral disc (IVD) is a complex and load bearing structure. IVD undergoes a process of change with age and leads to failures. This paper presents a novel model to detect IVD failures using Magnetic Resonance (MR) images. The proposed method makes use of Vertebrae Statisti...

BACKGROUND Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the years. Acute physical trauma or prolonged intervertebral disc mistreatment triggers a biochemical negative tendency of catabolic-anabolic balance th...

Introduction – aim The response of the intervertebral disc to asymmetric forces may accelerate degeneration through changes in the matrix. At a macroscopic level the disc sustains structural changes which may play a role in the progression of a scoliotic curve. At a molecular level, disc degeneration is the outcome of the action of matrix metalloproteases (MMPs), members of a family of enzymes ...

The intervertebral disc is a complex structure responsible for flexibility, multi-axial motion, and load transmission throughout the spine. Importantly, degeneration of the intervertebral disc is thought to be an initiating factor for back pain. Due to a lack of understanding of the pathways that govern disc degeneration, there are currently no disease-modifying treatments to delay or prevent d...

BACKGROUND The negative effect of long-term working load on lumbar is widely known. However, insertion of different resting modes on long-term working load, and its effects on the lumbar spine is rarely studied. The purpose of this study was to investigate the biomechanical responses of lumbar spine with different levels of degenerated intervertebral discs under different working-resting modes....

Intervertebral disc degeneration is the main cause of lumbago disease, in which the extracellular matrix structure and moisture in the nucleus pulposus is lost continuously. In this study, we aimed to detect differential expression of silence mating type information regulation 2 homolog 1 (SIRT1) and matrix metalloproteinase-1 (MMP-1) in human intervertebral disc nucleus pulposus cells and to e...

STUDY DESIGN A case report is presented. OBJECTIVE To highlight the potential for spontaneous resolution of large extruded intervertebral lumbar disc herniations in a patient with three independent herniations. SUMMARY OF BACKGROUND DATA The most effective methods of treatment for lumbar intervertebral disc herniations remain in question. This is partly because the potential for intrinsic s...

OBJECTIVE To study the effects of Yiqi Huayu Recipe on the gene expression pattern in normal and apoptotic chondrocytes in the cervical intervertebral disc of rats. METHODS The intervertebral disc endplates of rats were digested enzymatically. The apoptosis of the chondrocytes was induced by anti-Fas antibody. BiostarR-40s microarray chips were used to investigate the gene expression pattern ...

Cervical spine disorders such as spondylotic radiculopathy and myelopathy are often related to osteophyte formation. Bone remodeling experimental-analytical studies have correlated biomechanical responses such as stress and strain energy density to the formation of bony outgrowth. Using these responses of the spinal components, the present study was conducted to investigate the basis for the oc...

BACKGROUND Lumbar disc prolapse is a common problem and the current surgical standard for its treatment is a microsurgical discectomy. Microendoscopic discectomy (MED) is a minimally invasive spinal procedure being done successfully for prolapsed intervertebral disc disease. AIMS We report the technique, outcome and complications seen in 107 cases of prolapsed lumbar intervertebral disc who u...