A mathematical model of interstitial fluid flow is developed, based on the application of the governing equations for fluid flow, i.e., the conservation laws for mass and momentum, to physiological systems containing solid tumors. The discretized form of the governing equations, with appropriate boundary conditions, is developed for a predefined tumor geometry. The interstitial fluid pressure a...

Elevated tumor interstitial fluid pressure (IFP) is partly responsible for the poor penetration and distribution of therapeutic agents in solid tumors. The etiology of tumor interstitial hypertension is poorly understood. We have postulated that the solid stress generated by tumor cells growing in a confined space compresses blood vessels and increases tumor microvascular pressure and IFP. To t...

BACKGROUND Secreting interstitial cell (Leydig cell) tumors are rare. In adults, the clinical picture and steroid levels are variable. CASE PRESENTATION This paper presents a case of left testicular tumor, showing azoospermia with normal serum level of total testosterone, collapsed FSH and LH, and high delta4 androstenedione. Histopathological investigation revealed a Leydig cell tumor. TESE ...

During tumor development, constant interplay occurs between tumor cells and surrounding stromal cells. We report evidence that gastrointestinal stromal tumor (GIST) cells invade the interstitial stroma through the release of the oncogenic protein tyrosine kinase (KIT)-containing exosomes, which triggers the phenotypic conversion of progenitor smooth muscle cells to tumor-promoting cells. These ...

In this work, we present and analyze a mathematical model for tumor growth incorporating ECM erosion, interstitial flow, the effect of vascular flow nutrient transport. The is phase-field or diffused-interface type in which multiple phases cell species other constituents are separated by smooth evolving interfaces. involves mesoscale version Darcy’s law to capture mechanism tissue matrix. Model...

congenital epulis is a very rare benign soft-tissue tumor of uncertain histogenesis, which is also known as “gingival granular cell tumor of the newborn”. it occurs almost exclusively as a single tumor along the alveolar ridge of the maxilla in newborn females. although congenital epulis is strikingly similar to the more common adult granular cell tumor histologically, in contrast to the latter...

granular cell tumor (gct) was first described by abrikossoff in 1926. gct is a rarely seen soft tissue tumor and is generally benign. while the tumor can be seen in all parts of the body it is generally located on the head and neck region, and especially on the tongue. gct is rarely seen in the anal-perianal region. in accordance with literature this case was reported because it was thought to ...

intra-abdominal desmoplastic small round cell tumor is a rare entity with a few reports worldwide. this tumor commonly occurs in children and adolescent and occurrence in adult age group is very rare. here, we describe an adult male with symptoms of intestinal obstruction due to abdominal mass, located in splenic flexure. after resection, the diagnosis of intra-abdominal desmoplastic small roun...

background and objectives: giant cell tumor of bone (gct) is often regarded as a benign tumor, but its clinical course is unpredictable, has a high rate of recurrence, and even can metastases and transform to a malignant tumor. histological features of the tumor often could not predict its future biologic behavior, so it is just called ''giant cell tumor'' without indicating malignancy or benig...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 there are a few case series of giant cell tumor (gct) in the spine and sacrum. gct in the thoracic vertebrae is even more exceptional in the medical literature. in this article we report a gct in a 25-year-old male who presented with progressive back pain and dyspnea. on contrast-enhanced multidetector computer tomography,...