BACKGROUND Kidney transplantation following uncontrolled donation after circulatory death (uDCD) presents a high risk of delayed graft function due to prolonged warm ischemia time. In order to minimise the effects of ischemia/reperfusion injury during warm ischemia, normothermic recirculation recently replaced in situ perfusion prior to implantation in several institutions. The aim of this stud...

Introduction In dynamic susceptibility contrast (DSC) MRI, the concentration time curves commonly do not return to baseline after the first pass. In normal brain tissues with intact blood-brain barrier (BBB), the elevated concentration during the recirculation phase could be caused by the intravascular contrast agents. However, when the BBB is disrupted, as the case with brain tumor, both the i...

We investigate flow in the stomach during gastric mixing using a numerical simulation with an anatomically realistic geometry and free-surface flow modeling. Because of momentum differences between greater and lesser curvatures during peristaltic contractions, time-averaged recirculation is generated in the antrum, with retropulsive flow away from the pylorus and compensation flow along the gre...

Accuracy and mesh generation are key issues for the high-resolution hydrodynamic modelling of the whole Great Barrier Reef. Our objective is to generate suitable unstructured grids that can resolve topological and dynamical features like tidal jets and recirculation eddies in the wake of islands. A new strategy is suggested to refine the mesh in areas of interest taking into account the bathyme...

We describe a new learning procedure for networks that contain groups of nonlinear units arranged in a closed loop. The aim of the learning is to discover codes that allow the activity vectors in a "visible" group to be represented by activity vectors in a "hidden" group. One way to test whether a code is an accurate representation is to try to reconstruct the visible vector from the hidden vec...

Previous therapeutic studies on the prevention of selective vulnerability of neurons in the hippocampus have suggested that the critical period for induction of delayed neuronal injury occurs early during recirculation. To determine the onset and duration of this period, an ultrashort-acting barbiturate (methohexital) was infused into the left carotid artery of 47 gerbils after various times of...

Controlled recirculation has been used in the metal/nonmetal mining industry for energy savings when heating and cooling air, in undersea mining and for increasing airflow to mining areas. For safe and effective use of controlled district recirculation, adequate airflow to dilute contaminants must exist prior to implementation, ventilation circuit parameters must be accurately quantified, venti...

A hybrid in situ bioremediation/pulsed pumping strategy has been developed to cost effectively remediate a carbon tetrachloride plume in Schoolcraft, Michigan. The pulsed pumping system uses a line of alternating injection and extraction wells perpendicular to the direction of natural groundwater flow. The wells pump periodically to clean the recirculation zone between adjacent wells. During th...

The free radical trapping agents NXY-059 and alpha-phenyl-N-tert.-butylnitrone (PBN) markedly reduce infarct volume, even when given 1 or 3 h after the start of recirculation, following 2 h of middle cerebral artery (MCA) occlusion in rats. Their anti-ischemic effects are shared by the two immunosuppressants cyclosporin A (CsA) and FK506. Interestingly, CsA causes an additional reduction in inf...

Previous therapeutic studies on the prevention of selective vulnerability of neurons in the hippocampus have suggested that the critical period for induction of delayed neuronal injury occurs early during recirculation. To determine the onset and duration of this period, an ultrashort-acting barbiturate (methohexital) was infused into the left carotid artery of 47 gerbils after various times of...