IMPORTANCE Olfaction is a complex sensory process that has not been fully studied. Elevated plasma levels of interleukin 6 (IL-6) have been found in patients with several acute and chronic diseases but have not been reported in patients with smell loss (hyposmia). OBJECTIVE To determine IL-6 levels in patients with hyposmia. DESIGN Retrospective study. All measurements were made without ref...

Diabetes mellitus can cause a decrease in tear secretion and film composition, resulting series of pathological changes such as the stability film, increased risk inflammation, peripheral neuropathy impairment meibomian glands, leading to dry eye. The imbalance inflammatory mediators diabetic patients injury ocular surface are main factors that aggravate Nod-like receptor protein 3 inflammasome...

Curcumin has been shown to have numerous cytotoxic effects on cancer stem cells (CSCs). This is due to its suppression of the release of cytokines, particularly interleukin (IL)-6, IL-8 and IL-1, which stimulate CSCs, and also to its effects at multiple sites along CSC pathways, such as Wnt, Notch, Hedgehog and FAK. In spite of its multiple actions targeting CSCs, curcumin has little toxicity a...