Interleukin (Ib12) has many effects on the function of natural killer and T cells, and is important in the control of cell-mediated immunity. IL-2 and IL-12 display many similar activities, yet each also induces a distinct set of responses. A human IL-12 receptor subunit has recently been cloned and, like the IL-2R,8 and IL-2R% is a member of the hematopoietic receptor superfamily; however, the...

Interleukin (IL)-10, a multifunctional immune-regulatory cytokine with both immunosuppressive and anti-angiogenic functions, is produced by immune cells including macrophages, T lymphocytes, and natural killer cells. Among other effects, IL-10 promotes tumor cell proliferation and metastasis via immunosuppression. Interleukin-10-mediated immunosuppression is aided by synthesis of tumor necrosis...

Lipopolysaccharide (LPS) increases the production of interleukin-12 (IL-12) from mouse macrophages via a kappaB site within the IL-12 p40 promoter. In this study, we found that retinoids inhibit this LPS-stimulated production of IL-12 in a dose-dependent manner. The NFkappaB components p50 and p65 bound retinoid X receptor (RXR) in a ligand-independent manner in vitro, and the interaction inter...

background : the current study was designed to evaluate immune responses induced by dna vaccines encoding 8-kda subunit of antigen b (hydi) of echinococcus granulosus and murine interleukin 12 (il-12) as genetic adjuvants in balb/c mice. methods : expression plasmid pcdna3.1 containing hydi (pchyd1) as vaccine along with the murine interleukin 12 (pcmil12) as adjuvant were used. thirty-five mic...

The pro-Th2 cytokine IL-33 is now emerging as an important Th1 cytokine-IFN-γ inducer in murine CD4(+) T cells that is essential for protective cell-mediated immunity against viral infection in mice. However, whether IL-33 can promote human Th1 cell differentiation and how IL-33 polarizes Th1 cells is less understood. We assessed the ability of IL-33 to induce Th1 cell differentiation and IFN-γ...

Resistance to infection by Leishmania major has been associated with the development of a Th1 type response that is dependent on the presence of interleukin 12 (IL-12). In this work the involvement of this cytokine in the response to infection by L. braziliensis, a less virulent species in the mouse model, was evaluated. Our results show that while interferon (IFN-gamma) deficient (-/-) mice in...

interleukin-12 (il-12) is a key cytokine involved in regulating the balance between th1 and th2 cells by promoting th1 response. a reduced capacity to produce this cytokine could lead to aberrant th2 development. on the same aspect significant impact of il-12 on invariant natural killer t (inkt) cells was reported. therefore, we examined the serum levels of il-12 and the absolute number of peri...