To clarify the underlying mechanism of radioresistance nasopharyngeal carcinoma, we identified correlated gene modules and key genes through analyzing expression omnibus dataset with weighted co-expression network analysis. GSE32389 were obtained from omnibus. The analysis was introduced to establish a mine important genes. Gene ontology enrichment performed in which related carcinoma. Then, es...

conclusions this case showed the effect of additional anakinra on children with fmf who were colchicine resistant. case presentation herein was reported a colchicine non-responsive patient with accurate diagnosis and early treatment of fmf. she had presented with recurrent and persistent acute abdominal pain attacks and several abdominal surgeries. addition of recombinant interleukin-1 receptor...

Coronary heart disease (CHD) is among the most serious worldwide health problems. Recent genetic studies have robustly identified a number of polymorphic loci throughout the genome that are associated with disease risk but it is certain that more remain to be discovered. It is well established that inflammation plays a key role in the pathophysiology of CHD. Determining whether or not polymorph...

Cluster of differentiation 47-thrombospondin 1 is newly discovered pathway as T-cell stimulatory signal can induce immune tolerance that provides a new idea for the therapy acute graft vs. host disease after transplantation haploid. However, numerous studies have found regulation cluster on system bi-directional. Currently specific mechanisms promotes unclear. The model with 47 monoclonal antib...

There is considerable evidence that polymorphisms in the regulatory regions of cytokine genes are highly influenced by ethnicity. Polymorphisms in interleukin 1-beta (IL-1beta) and IL-1 receptor antagonist (IL-1Ra) genes, respectively encoding a potent inflammatory agent and an antagonist, which combines with IL-1 receptors competitively, have been associated with a number of diseases like syst...