interferon lambda 3

α-Interferon is an antiviral agent used in treatment of chronic hepatitis B. Triggering of the underlying autoimmune disease or exacerbation of pre-existing auto immune disease is documented with α-interferon, but there are few reports about occurrence of autoimmune disorders such as systemic lupus erythematosus, Vitiligo, hypo and hyperthyroidism after administration of α-interferon in the lit...

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Complete $$\lambda $$-surfaces in $${\mathbb {R}}^3$$

Journal: :Calculus of Variations and Partial Differential Equations 2021

The purpose of this paper is to study complete $$\lambda $$ -surfaces in Euclidean space $${\mathbb {R}}^3$$ . A classification for 2-dimensional $$\mathbb R^3$$ with constant squared norm the second fundamental form given, which confirms a conjecture Guang (Self-shrinkers and translating solitons mean curvature flow, 2016, p 74).

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IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance

2015

Yi-Fan Lu David M. Mauger David B. Goldstein Thomas J. Urban Kevin M. Weeks Shelton S. Bradrick

Polymorphisms near the interferon lambda 3 (IFNL3) gene strongly predict clearance of hepatitis C virus (HCV) infection. We analyzed a variant (rs4803217 G/T) located within the IFNL3 mRNA 3' untranslated region (UTR); the G allele (protective allele) is associated with elevated therapeutic HCV clearance. We show that the IFNL3 3' UTR represses mRNA translation and the rs4803217 allele modulate...

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