Background Developmental dyscalculia is a primary cognitive disorder of childhood affecting the ability of an otherwise intelligent and healthy child to learn arithmetic.' Preliminary evidence indicates that developmental dyscalculia is seen in 5-6% of normal children2 3 and is as prevalent as developmental dyslexia or the attention deficit hyperactivity disorder.' One of the classifications of...

Rubinstein-Taybi syndrome is characterized by a broad thumb and bulbous hallux, short stature, intellectual disability and distinctive facial features [1]. It is a rare neuro-developmental disorder with a reported prevalence of 1 in 1,25,000 births [2]. Psychosis in RTS is highly infrequent with only a few scattered case reports [3]. A comprehensive literature search yielded only one case repor...

Microdeletions in chromosome 17q22, where the NOG gene resides, have been reported leading to the NOG-related symphalangism spectrum disorder (NOG-SSD), intellectual disability and other developmental abnormalities. In this study we reported a dominant Chinese Han family segregating with typical NOG-SSD symptoms including proximal symphalangism, conductive hearing loss, amblyopia and strabismus...

introduction: attention deficit / hyperactivity disorder (adhd) is a persistent pattern of inattention and/or hyperactivity - impulsivity behavior. adhd is frequently accompanied by developmental coordination disorder (dcd). motor coordination is a complex performance of interaction between visual perceptual, neuromuscular coordination, memory, attention and balance. one of the most important p...

It is quite known that defects in brain function especially in children usually may result in neuro-developmental disorders such as intellectual disability, Attention-Deficit/Hyperactivity Disorder (ADHD), autism, and learning disabilities which is reflected in disabilities to communicate, move or behave. These symptoms usually change with age, although some children may develop permanent disab...

Down syndrome (DS, trisomy 21), is the most common viable chromosomal disorder, with an incidence of 1 in 800 live births. Its phenotypic characteristics include intellectual impairment and several other developmental abnormalities, for the majority of which the pathogenetic mechanisms remain unknown. In this "Data in Brief" paper, we sum up the whole genome analysis by mRNA sequencing of norma...

AIM Chromosome microarray (CMA) can determine copy number variants such as microdeletions or microduplications. Microdeletions of movement disorder genes including epsilon-sarcoglycan (SGCE) and thyroid transcription factor-1 (TITF1) have been described in patients with myoclonus dystonia and benign hereditary chorea respectively. We examined whether CMA is a valuable tool in the investigation ...

OBJECTIVE To characterize wandering, or elopement, among children with autism spectrum disorder (ASD) and intellectual disability. STUDY DESIGN Questions on wandering in the previous year were asked of parents of children with ASD with and without intellectual disability and children with intellectual disability without ASD as part of the 2011 Survey of Pathways to Diagnosis and Services. The...

UNLABELLED De novo truncating mutations in ARID1B, a chromatin-remodeling gene, cause Coffin-Siris syndrome, a developmental disorder characterized by intellectual disability and speech impairment; however, how the genetic elimination leads to cognitive dysfunction remains unknown. Thus, we investigated the neural functions of ARID1B during brain development. Here, we show that ARID1B regulates...