Of all the age-related declines, memory loss is one of the most devastating. While conditions that increase longevity have been identified, the effects of these longevity-promoting factors on learning and memory are unknown. Here we show that the C. elegans Insulin/IGF-1 receptor mutant daf-2 improves memory performance early in adulthood and maintains learning ability better with age but, surp...

The authors provide a nice summary of our recent report on how growth hormone (GH) regulates neonatal inflammatory pain.We still need to understand how GH is downregulated during peripheral injury and how this reduction causes a paradoxical increase in sensory neuron IGFr1. To clarify, IGF-1 was not statistically increased in the skin as suggested. Furthermore, although not confirmed in vivo, i...

Insulin-like growth factor (IGF)-1 is associated with a higher risk of prostate cancer. IGF-binding protein (IGFBP)-1, a marker for insulin activity, also binds IGF-1 and inhibits its action. Data on IGFBP-1 and prostate cancer risk are sparse and whether the IGF and insulin axes interact to affect prostate cancer carcinogenesis is unknown. We evaluated the independent and joint influence of pr...

There is evidence to suggest that fractures heal more rapidly in patients with a head injury as a result of systemic factors released from the site of this injury. We have measured the circulating level of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) in serum because of their known involvement in the stimulation of the activity of osteoblasts and the healing of fract...

Introduction: Biochemical markers play an important role in the growth and repair of bone and can be evaluated in different biological fluids. Therefore, the aim of this study was to evaluate the level of insulin-like growth factor-I (IGF-I) in urine as a puberty index and to compare it with cervical vertebral maturational stages (CVMSs) in lateral cephalometry. Materials&Methods: In this cros...

abstract introduction: there is limited knowledge available on the metabolism of glucose in the brain, an insulin insensitive organ. insulin receptors hybridize with insulin like growth factor receptor (igf-i) to transduce the signals in different areas of the brain. in this article we aimed at investigating whether the expression of igf-i receptor and igf-i binding proteins (igfbp1) is changed...

BACKGROUND Cell-based therapy has been implicated in the treatment of liver diseases. Mesenchymal stem cells from various sources such as bone marrow are available. These cells are one of the major candidates in cell therapy. The production of insulin-like growth factor-I increases in the regenerating organ. The insulin-like growth factor-I in liver regeneration is effective after binding to in...