Growth factor receptor-bound protein 10 (Grb10) is an adapter protein that interacts with a number of tyrosine-phosphorylated growth factor receptors, including the insulin receptor (IR). To investigate the role of Grb10 in insulin signaling, we generated cell lines in which the expression levels of Grb10 are either overexpressed by stable transfection or suppressed by RNA interference. We foun...

BACKGROUND Cogent evidence has shown that schizophrenia vulnerability is enhanced by psychosocial stress in adolescence, yet the underpinnings of this phenomenon remain elusive. One of the animal models that best capture the relationship between juvenile stress and schizophrenia is isolation rearing (IR). This manipulation, which consists in subjecting rats to social isolation from weaning thro...

In this paper we first define a reduction Æ that transforms an instance of Regular-SAT into a satisfiability equivalent instance Æ of SAT. The reduction Æ has interesting properties: (i) the size of Æ is linear in the size of , (ii) Æ transforms regular Horn formulas into Horn formulas, and (iii) Æ transforms regular 2-CNF formulas into 2-CNF formulas. Second, we describe a new satisfiability t...

How can we explain Central and Eastern Europe’s (CEE) relative absence in the ‘worlding International Relations’(IR) conversation? What does provincializing discipline from CEE might look like? I argue that has been relatively neglected IR’ literature 1) due to local factors, 2) because it have turned into an ‘unimportant other’, 3) history of region challenges macro-categories – ‘West/non-West...

We present a new multiple-instance (MI) learning technique (EMDD) that combines EM with the diverse density (DD) algorithm. EM-DD is a general-purpose MI algorithm that can be applied with boolean or real-value labels and makes real-value predictions. On the boolean Musk benchmarks, the EM-DD algorithm without any tuning significantly outperforms all previous algorithms. EM-DD is relatively ins...

Consider the setting where judges are repeatedly asked to (partially) rank sets of objects, and assume that each judge tries to reproduce some true underlying ranking to the best of their ability. Rank aggregation aims to combine the rankings of such experts to produce a better joint ranking, and is a ubiquitous problem in Information Retrieval (IR) and Natural Language Processing (NLP). In IR,...

Starting with exact solutions to string theory on curved spacetimes we obtain deformations that represent gravitational shock waves. These may exist in the presence or absence of sources. Sources are effectively induced by a tachyon field that randomly fluctuates around a zero condensate value. It is shown that at the level of the underlying conformal field theory (CFT) these deformations are m...

Relative entropy methods have received a lot of attention in the last few years not only in the context of linear parabolic equations [12,1] but also to handle nonlinear diffusion problems [11,5,7,4,9] and get decay estimates and asymptotic diffusion results. The goal of this letter is to give results on intermediate asymptotics for general nonlinearities. Here, we are not concerned with existe...

BACKGROUND The optimal method for the reduction and fixation of posterior malleolar fracture (PMF) remains inconclusive. Currently, both of the indirect and direct reduction techniques are widely used. We aimed to compare the reduction quality and clinical outcome of posterior malleolar fracture managed with the direct reduction technique through posterolateral approach or the indirect reductio...