Genetic instability in Streptomyces ambofaciens DSM 40697 is correlated with genomic instability characterized by multiple rearrangements (deletions and/or amplifications) occurring in a large unstable region. We have focused on one of the two amplifiable DNA loci which were mapped in this region: the amplifiable unit of DNA locus 6 (AUD6). The nucleotide sequence of one AUD6 fragment of 1.9 kb...

The proposed 1-MW spallation neutron source upgrade calls for a 2-GeV rapidly-cycling synchrotron (RCS) with an intensity of 1 . 0 4 ~ 1 0 ~ ~ protons per pulse [l]. The potential exists for the excitation of collective, intensity-dependent transverse instabilities. These can normally be controlled by introducing a betatron tune shift or spread, where care is exercised to avoid single-particle ...

We analyze a numerical instability that occurs in the well-known split-step Fourier method on the background of a soliton. This instability is found to be very sensitive to small changes of the parameters of both the numerical grid and the soliton, unlike the instability of most finite-difference schemes. Moreover, the principle of “frozen coefficients”, in which variable coefficients are treat...

We examine the linear stability of fluid interfaces subjected to a shear flow. Our main object is to generalize previous work to an arbitrary Atwood number, and to allow for surface tension and weak compressibility. The motivation derives from instances in astrophysical systems where mixing across material interfaces driven by shear flows may significantly affect the dynamical evolution of thes...

OBJECTIVE Mutator phenotypes with microsatellite instability (MSI) are observed in a subset of solid tumors including those localized in the brain. MSI arises from impaired DNA mismatch repair. It can be a potential marker of resistance to radiation and chemotherapy, as demonstrated for several cancer types. Our study aims are to investigate MSI incidence in pituitary adenomas (PA) with a curre...

Software instability measures indicate the necessity to modify a software module (class, package, subsystem, etc) due to changes in other related software entities. If there is low instability, then there is evidence the analyzed entity has little dependence on others and the project has a good maintainability. Otherwise, there is evidence that the analyzed entity is sensitive to changes occurr...

Capillary instability of a viscous fluid cylinder of diameter D surrounded by another fluid is determined by a Reynolds number J = V D `= `, a viscosity ratio m = a= ` and a density ratio ` = a= `. Here V = = ` is the capillary collapse velocity based on the more viscous liquid which may be inside or outside the fluid cylinder. Results of linearized analysis based on potential flow of a viscous...