Institute for Theoretical Physics (KITP) and the first incumbent of the Frederick W. Gluck Chair in Theoretical Physics at the University of California, Santa Barbara, was awarded the 2004 Nobel Prize in Physics for solving in 1973 the last great remaining problem of what has since come to be called “the Standard Model” of the quantum mechanical picture of reality. He and his co-recipients disc...

Wormholes have been advanced as both a method for circumventing the limitations of the speed of light as well as a means for building a time machine (to travel to the past). Thus it is argued that General Relativity may allow both of these possibilities. In this note I argue that traversable wormholes connecting otherwise causally disconnected regions, violate two of the most fundamental princi...

Aquatic and semiaquatic mammals have the capacity of breath hold (apnea) diving. Northern elephant seals (Mirounga angustirostris) have the ability to perform deep and long duration dives; during a routine dive, adults can hold their breath for 25 min. Neotropical river otters (Lontra longicaudis annectens) can hold their breath for about 30 s. Such periods of apnea may result in reduced oxygen...

BACKGROUND Inosine triphosphate (ITP) pyrophosphohydrolase (ITPA) catalyzes the pyrophosphohydrolysis of ITP/dITP and xanthosine triphosphate to prevent incorporation of unusual nucleotides into RNA and DNA. Important mutations leading to enzyme deficiency are 94C>A and IVS2 + 21A>C. An association between ITPA 94C>A and adverse reactions during azathioprine treatment has been shown. To investi...

Ribavirin (RBV) has been widely used as an antiviral reagent, specifically for patients with chronic hepatitis C. We previously demonstrated that adenosine kinase, which monophosphorylates RBV into the metabolically active form, is a key determinant for RBV sensitivity against hepatitis C virus RNA replication. However, the precise mechanism of RBV action and whether RBV affects cellular metabo...

We demonstrate that any scale-invariant mechanics of one variable exhibits not only 0+1 conformal symmetry, but also the symmetries of a full Virasoro algebra. We discuss the implications for the adS/CFT correspondence.

Adenosine triphosphatase (ATPase) activity in the rectal papillae of Calliphora has been studied by biochemical and histochemical techniques. The microsomal fraction contained a Mg-activated ATPase with a pH optimum of 8-o. The enzyme was not stimulated by the addition of Na+ plus K+ and was insensitive to ouabain. Histochemical studies using modifications of the Wachstein-Meisel method showed ...

Graft vascular disease after solid organ transplantation is a main complication that limits long-term survival of the graft. An injury of the endothelium and subsequent vascular response is considered to be responsible for smooth muscle cell hyperplasia with resulting luminal narrowing. What is less certain are the precise steps leading to endothelial injury and subsequent vessel disease. Since...