CONCLUSION Cell transplantation into the utriculus provides an efficient and non-invasive route to introduce embryonic stem (ES) cells into the vestibular and cochlear portions of the inner ear. OBJECTIVE The transfer of stem cells into the inner ear for therapeutic purposes is an important approach to cure damage to the cochlea and vestibulum. A key issue is to provide an entry point for cel...

OBJECTIVE To investigate the effects of the virulence characteristics of specific pneumococcal proteins on the inner ear. MAIN OUTCOME MEASURES A histologic comparison of inflammatory cell infiltration and pathologic changes in the round window membrane and inner ear. RESULTS Most of the animals inoculated with high-dose pneumolysin or wild-type bacteria showed severe pathologic changes of ...

A colored line flanking a darker contour will appear to spread its color onto an area enclosed by the line (watercolor effect). The watercolor effect has been characterized as an assimilative effect, but non-assimilative color spreading has also been demonstrated in the same spatial configuration; e.g., when a black inner contour (IC) is paired with a blue outer contour (OC), yellow color sprea...

STUDY OBJECTIVE The purpose of the study was to assess the accuracy of Family Practitioner Committee (FPC) lists for identifying very elderly people registered with general practitioners. DESIGN The accuracy of available FPC lists was checked against the most recent electoral register to determine which recorded individuals were still living at their FPC registered addresses. This was followe...

The inner ear is a highly specialized mechanosensitive organ responsible for hearing and balance. Its small size and difficulty in harvesting sufficient tissue has hindered the progress of molecular studies. The protein components of mechanotransduction, the molecular biology of inner ear development and the genetic causes of many hereditary hearing and balance disorders remain largely unknown....

Due to the physics of magnetic fields and forces, any single magnet will always attract or pull-in magnetically-responsive particles. However, there are a variety of clinical needs where it is advantageous to be able to push away or ‘magnetically inject’ therapeutic particles. Here we focus on magnetic injection to treat inner-ear diseases. The inner ear is behind the blood-ear barrier, meaning...

INTRODUCTION Congenital abnormalities of the inner ear is the most common cause of neurosensory hearing loss. Michel inner ear deformity is a rare developmental anomaly refers to the total aplasia of the inner ear. It is caused by developmental arrest of otic placode early during the third week of gestational age. CASE REPORT We have discussed here that three year old girl diagnosed Michel ap...