The methodological advancements made in the field of joint models are numerous. None less, case competing risks has largely been neglected, especially from a practitioner's point view. In relevant works on models, assumptions Gaussian linear longitudinal series and proportional cause-specific hazard functions, amongst others, have remained unchallenged. this article, we provide framework based ...

Integrated nested Laplace approximation (INLA) provides a fast and yet quite exact approach to fitting complex latent Gaussian models which comprise many statistical models in a Bayesian context, including log Gaussian Cox processes. This paper discusses how a joint log Gaussian Cox process model may be fitted to independent replicated point patterns. We illustrate the approach by fitting a mod...

We present a non-factorized variational method for full posterior inference in Bayesian hierarchical models, with the goal of capturing the posterior variable dependencies via efficient and possibly parallel computation. Our approach unifies the integrated nested Laplace approximation (INLA) under the variational framework. The proposed method is applicable in more challenging scenarios than ty...

In this report, we investigate the use of INLA, (Martino and Rue, 2008) to solve Bayesian inferential problems in Bayesisan Survival analsysis. In particular we consider the Exponential and Weibulldistributed lifetimes with and without censoring and frailty, and Cox-models with piecewise constant and piecewise linear baseline hazard. We demonstrate that all these models can (in most cases) be e...

Abstract Background Listeria monocytogenes is a widespread foodborne pathogen that causes listeriosis, human infection with low morbidity but high mortality. Internalin A (InlA), L. virulence factor, has key role in the invasion of intestinal epithelium through interaction E-cadherin receptor. Truncated InlA caused by premature stop-codons (PMSC) have been correlated attenuated virulence. To da...

The human pathogen Listeria monocytogenes is a large concern in the food industry where its continuous detection in food products has caused a string of recalls in North America and Europe. Most recognized for its ability to grow in foods during refrigerated storage, L. monocytogenes can also tolerate several other food-related stresses with some strains possessing higher levels of tolerances t...

Some Listeria monocytogenes internalins are recognized as contributing to invasion of mammalian tissue culture cells. While PrfA is well established as a positive regulator of L. monocytogenes virulence gene expression, the stress-responsive sigma(B) has been recognized only recently as contributing to expression of virulence genes, including some that encode internalins. To measure the relativ...

Abstract Double hierarchical generalized linear models (DHGLM) are a family of that flexible enough as to model hierarchically the mean and scale parameters. In Bayesian framework, fitting highly parameterized is challenging when this problem addressed using typical Markov chain Monte Carlo (MCMC) methods due potential high correlation between different parameters effects in model. The integrat...