BACKGROUND Acute traumatic coagulopathy (ATC) is a syndrome of early, endogenous clotting dysfunction that afflicts up to 30% of severely injured patients, signaling an increased likelihood of all-cause and hemorrhage-associated mortality. To aid identification of patients within the likely therapeutic window for ATC and facilitate study of its mechanisms and targeted treatment, we developed an...

BACKGROUND The early prediction of acute kidney injury (AKI) by current clinical and laboratory methods remains inadequate. Neutrophil gelatinase-associated lipocalin (NGAL) has emerged as a promising non-invasive biomarker of kidney injury. We systematically reviewed the utility of plasma and urine NGAL measurements for the prediction of AKI in humans. METHODS We searched MEDLINE, PubMed and...

this is an observational case series study on penetrating trauma admissions in three teaching hospitals in tehran from 1996 to 1997. in order to describe the epidemiology and determine the ways of improving treatment of penetrating injuries, we selected 410 patients with penetrating injuries and injury severity scores (iss) of more than 7 (the maximum iss is 75) out of 3580 trauma patients, hos...

The Rugby Injury and Performance Project (RIPP) is a prospective cohort study by a multidisciplinary research group. Rugby injuries constitute an important area for research because rugby union is New Zealand's national sport and because of the considerable cost of all sports injury acknowledged by the Accident Rehabilitation and Compensation Insurance Corporation (ACC). The initial phase of da...

Head injury is the leading cause of fatality and long-term disability for children. Pediatric heads change rapidly in both size and shape during growth, especially for children under 3 years old (YO). To accurately assess the head injury risks for children, it is necessary to understand the geometry of the pediatric head and how morphologic features influence injury causation within the 0-3 YO ...

This paper presents an estimate of the probability of serious occupant injury in frontal crashes based on vehicle kinematics information. Occupant injury risk is developed by modeling the human as a point mass and computing the occupant impact velocity (OIV) using the flail space model. Event Data Recorder data provide vehicle kinematics information for real world crashes with known injury outc...

Advanced Human Body FE models are now being used extensively in the development process of vehicle safety systems. This tool on one hand aids in the optimization of restraint systems and on the other hand also provides a detailed analysis of injury mechanisms when used within accident reconstruction. A good documented (injury patterns & physical loading conditions) real world crash and its reco...

INTRODUCTION The Injury Severity Score (ISS) and the New Injury Severity Score (NISS) are widely used for anatomic severity assessments after trauma. We present here the Tangent Injury Severity Score (TISS), which transforms the Abbreviated Injury Scale (AIS) as a predictor of mortality. MATERIAL AND METHODS The TISS is defined as the sum of the tangent function of AIS/6 to the power 3.04 mul...

Increasing evidence suggests that neighborhood-based measures of socioeconomic status are correlated with traffic injury. The main objective of this study is to determine the differences in associations between predictive variables and injury crashes (i.e. including injury and fatal crashes). To this end, crash data, socio-demographic, socioeconomic characteristics and road network variables ar...

Background: S-100B protein is a promising marker of injury severity and outcome after head injury. Objective: The aim of this study was to consider the diagnostic and prognostic validity of the initial serum levels of S-100B in clinical use. Patients and Methods: Thirty patients with mild and moderated traumatic brain injury were included in this prospective study between June 2010 and June 201...