In previous works, we reported the fabrication of cotton-wool-like composites consisting of siloxane-doped vaterite and poly(l-lactic acid) (SiVPCs). Various irregularly shaped bone voids can be filled with the composite, which effectively supplies calcium and silicate ions, enhancing the bone formation by stimulating the cells. The composites, however, were brittle and showed an initial burst ...

Liposomal nanohybrid cerasomes display a remarkable ability to maintain their size and retain encapsulated doxorubicin (DOX) over a period of 90days under storage conditions in solution compared with liposomes and liposils. Cerasomes retained 92.1±2.9% of the drug payload after 90days storage, much more than liposomes (35.2±2.5%) and liposils (53.2±5.5%). Under physiologically relevant conditio...

The aim of this work was to study the effect of several process parameters used during pellets coating in two wurster fluid beds of different scales on: a) the uniformity of pellets coating, and b) the presence of an initial burst in the release profile caused by the existence of a significant fraction of pellets having a very thin film coating. The pellets used in this work presented high insu...

In this paper, we propose a new preemptive scheme with release message in optical burst switching (OBS) networks. In the proposed scheme, when a low priority burst is preempted at some intermediate node, two RELEASE messages are sent immediately from the intermediate node to both source and destination nodes (two-way release message transmission), and the RELEASE messages release the correspond...

Intracellular distribution of siRNA after in vitro transfection typically depends on lipopolyplexes, which must release the siRNA into the cytosol. Here, the fate of siRNAs was monitored by FRET-based live cell imaging. Subsequent to in situ observation of uptake and release processes, this approach allowed the observation of a number of hitherto uncharacterized intracellular distribution and d...

Objective(s): Nanoparticles (NPs) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. The main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier for oral delivery. Methods: In this study, me...

Objective: Burst release of drugs occurs in a very short time compared to the entire sustained release process, yet it has not been specifically investigated in most of the work whereas our study aims the investigation of the burst release of antimicrobial agents from various collagen scaffolds and the release kinetics of antimicrobial agents from the collagen scaffolds. Materials and Methods: ...

A Box-Behnken design with three replicates was used for preparation and evaluation of Eudragit vancomycin (VCM) nanoparticles prepared by double emulsion. The purpose of this work was to optimize VCM nanoparticles to improve the physicochemical properties. Nanoparticles were formed by using W1/O/W2 double-emulsion solvent evaporation method using Eudragit RS as a retardant material. Full factor...

This study demonstrated that exposure of cultured human aortic smooth muscle cells (SMC) to fluid flow resulted in nitric oxide (NO) production, monitored by nitrite and guanosine 3',5'-cyclic monophosphate production. A rapid burst in nitrite production rate was followed by a more gradual increase throughout the period of flow exposure. Neither the initial burst nor the prolonged nitrite produ...

The serotonin (5-HT)-induced synaptic plasticity of Aplysia sensorimotor synapses has typically been probed by firing a single presynaptic spike. In the present study, 5-HT-induced synaptic plasticity was probed with brief bursts of spikes (10 Hz, 1 sec), which are more behaviorally relevant stimuli. Because such bursts provide a greater challenge to the release machinery than single spikes, th...