Gittleman syndrome (GS) is autosomal recessive renal tubulopathy caused by mutation of genes encoding protein for sodium chloride cotransporter and magnesium channel in the distal convoluted tubule.1 We present case a-20-years old female patient admitted our Internal Medicine Department recurrent hypokalaemia. She presented with quadriparesis. There was no history taking inhaled salbutamol, ins...

Insulin is the most effective blood glucose lowering agent and remains one of the cornerstones of diabetes management. However, many individuals with diabetes are either reluctant to initiate or are nonadherent to their insulin therapy for various reasons, including fear of frequent injections. Technosphere Insulin (TI) is a novel inhaled insulin powder that is approved by the United States Foo...

OBJECTIVE To develop a self-administered questionnaire to address alternative delivery routes of insulin and to investigate aspects of patient satisfaction that may be useful for subsequent assessment and comparison of an inhaled insulin regimen and a subcutaneous insulin regimen. RESEARCH DESIGN AND METHODS Attributes of patient treatment satisfaction with both inhaled and injected insulin t...

INTRODUCTION Inadequate glycemic control contributes to the development and progression of complications, which are associated with a significant economic burden on healthcare systems. However, optimal glycemic control is difficult to sustain with oral antidiabetic agents and adherence to intensive insulin regimens is compromised by patient compliance to multiple daily injections. Therefore, al...

Rosenstock J, Zinman B, Murphy LJ, et al. Inhaled insulin improves glycemic control when substituted for or added to oral combination therapy in type 2 diabetes: a randomized, controlled trial. Ann Intern Med 2005;143:549–58. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

Prior pertussis vaccination increased the sensitivity of mice to intraperitoneal injections of insulin and of sodium bicarbonate, but it reduced their sensitivity to high levels of inhaled carbon dioxide.