The inflammatory cytokine interleukin-6 (IL-6) has been linked to poor health outcomes in older adults. Oxidative stress triggers the production of IL-6, and antioxidant micronutrients play a critical role in decreasing this inflammatory response. The authors sought to identify the relations between serum levels of antioxidant nutrients and IL-6 and mortality in older women. Levels of aand b-ca...

A ConservativeMethod to Gutter Splint Ingrown Toenails Ingrown toenails can be due to trauma, improper nail cutting, and/or anatomic abnormalities of the nail apparatus. In the setting of normal anatomy, they are usually treated conservatively, but the presence of a sharp edge of the nail in the ulcer may prevent wound healing. Isolation of the nail plate from the ulcer bed using a gutter-shape...

Ingrown nail surgery is the one of the most common surgeries in outpatient clinics that are generally perfomed in response to patient complaints. Still, making simple observations, taking patient histories and conducting further tests are often neglected by outpatient clinics. Consequently, it is important to be aware if ingrown nail is associated with any underlying diseases that can lead to m...

A 39-year-old Caucasian male presented with a 5-year history of thickened toenail. The patient admitted that he used topical isoconazole nitrate twice daily for two months, without any improvement. The past medical history was unremarkable. The physical examination revealed subungual hyperkeratosis and onycholysis on the lateral side of the first toenail, onychoschizia of the second and fourth ...

Potential predictors of toenail selenium levels were studied in 1211 men and 1248 women aged 55-69 years. These subjects were randomly selected cohort members without prevalent cancer (other than skin) participating in a prospective study on diet and cancer in the Netherlands. Information on the considered potential predictors (gender, age, smoking, intake of dietary selenium and alcohol, Quete...

BACKGROUND Dietary factors such as folate, vitamin B12, protein, and methionine are important for the excretion of arsenic via one-carbon metabolism in undernourished populations exposed to high levels of arsenic via drinking water. However, the effects of dietary factors on toenail arsenic concentrations in well-nourished populations exposed to relatively low levels of water arsenic are unknow...

The authors report the case of a 34-year old patient with large botryomycoma of the big toe developed on an ingrown nail. The patient underwent surgical resection of the tumor and curative treatment of the ingrown nail. This tumor was considered exceptional due to its size: 2cm diameter, whose nature was confirmed by anatomopathologic study. The patient was scheduled for follow-up visits on a r...

BACKGROUND Accurate measurement tools of exposure for use in large epidemiologic studies are lacking. Biomarkers of tobacco exposure provide additional advantages to self-reports and there is a need to further develop and validate them. The objective is to compare toenail nicotine levels, a novel biomarker of tobacco exposure, with self-reports of tobacco exposure from a large cohort study. M...

Epidemiologic studies conducted in the US have not previously detected an association between regional drinking water arsenic concentrations and corresponding cancer occurrence or mortality rates. To improve our estimation of cancer risk and arsenic exposure in the USA, we have investigated the reliability of several exposure markers. In the current study, we specifically evaluated the long-ter...

BACKGROUND Selenium may prevent advanced prostate cancer (PCa), but most studies on this topic were conducted in populations with moderate to high selenium status. We investigated the association of toenail selenium, reflecting long-term selenium exposure, and advanced PCa risk in a population from the Netherlands where low selenium status is widespread. METHODS The analysis was conducted in ...