Introduction. Hepatic inflammation underlies the pathogenesis of chronic diseases such as insulin resistance and type 2 diabetes mellitus. S-[6]-Gingerol has been shown to have anti-inflammatory properties. Important inflammatory mediators of interleukins include nuclear factor κ B (NF κ B) and cyclooxygenase 2 (COX2). We now explore the mechanism of anti-inflammatory effects of S-[6]-gingerol ...

The aim of the study: to evaluate cytokine profile state in pregnant women with non-alcoholic fatty liver disease (NAFLD) at stage steatohepatitis (NASH) varying degrees obesity under influence developed complex therapy program. Material and methods. We examined 197 NAFLD NASH combination obesity. main group I consisted 98 obesity, who were divided into 3 subgroups depending on body mass index ...

Background: Polycystic ovary syndrome (PCOS) stands for highly prevalent female endocrine pathology. Females suffering from PCOS have a significantly higher number of inflammatory markers. The IL-1 family members enormously affect the innate immune system. Objectives: Study changes in levels Interleukin- 1ß and 27 stimulated non-stimulated cycle (by gonadotrophin) polycystic ovarian women. Meth...

conclusions increased serum levels of interleukins 6 and 8 as a predictive marker might be associated with unfavorable clinical outcome in patients with severe tbi. results comparing the serum levels of interleukins in two groups with favorable and unfavorable clinical outcomes showed that the mean serum levels of interleukins 6 and 8 in group with favorable outcome was 85.2 ± 51.6 and 52.2 ± 3...

PURPOSE OF REVIEW Recent literature in chronic rhinosinusitis with nasal polyps (CRSwNP) has focussed on inflammatory mechanisms underlying the disease. Endotyping the histopathological features of the disease, rather than simple clinical phenotypes, reflects a change in our understanding of the disease and approach to management. This is paralleled by renewed evidence for the need for wide pos...

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract involving aberrant activation of innate and adaptive immune responses. We have used two complementary models of IBD to examine the roles of interleukin (IL)-12 family cytokines in bacterially induced intestinal inflammation. Our results clearly show that IL-23, but not IL-12, is essential for the i...

Pain has both physical and emotional components. Physical noxious stimuli activate peripheral sensory neurons that, in turn, relay signals to the spinal and supraspinal nuclei. Subsequently, these signals activate areas within the brain associated with pain. Despite considerable knowledge in this area, analgesics may provide pain complete relief in only one out of five patients. Failure to mana...

Inflammation of the tonsils could be described as acute tonsillitis, mainly due to infection. Recurrent tonsillitis defined 3-7 episodes during first 3 years age. Vitamin D, which is a neuro-hormone with pleiotropic biological activities may modulate immune response by alleviation, and stimulation Th1 Th2 cell proliferation, respectively, that influence stimulation, synthesis, secretion both pr...