Objective(s): To investigate the effect of Ginkgo biloba extract EGb761 in early brain injury (EBI) after subarachnoid hemorrhage (SAH) and its mechanism. Materials and Methods: The SAH rat model was constructed and pre-treated with EGb761.The neurological function, severity of SAH, water content of brain tissue, damage degree of the blo...

Abstract The purpose of this paper is to explore the possible mechanisms anti-inflammatory and scar repair by Mongolian horse oil. We used TCM database literature mining collect active compounds oil Swiss TargetPrediction SuperPred server find targets compounds. Anti-inflammatory drug were collected through CTD database. Go annotation KEGG pathway enriched analyzed Metascape platform. Molecular...

Pro-inflammatory cytokines and bone morphogenetic proteins are generally studied separately and considered to be elements of different worlds, immunology and developmental biology. Varas and colleagues report that these factors show cross-talk in rheumatoid arthritis synoviocytes. They show that pro-inflammatory cytokines not only stimulate the production of bone morphogenetic proteins but that...

RATIONALE Atherosclerosis is initiated by blood flow patterns that activate inflammatory pathways in endothelial cells. Activation of inflammatory signaling by fluid shear stress is highly dependent on the composition of the subendothelial extracellular matrix. The basement membrane proteins laminin and collagen found in normal vessels suppress flow-induced p21 activated kinase (PAK) and nuclea...

Mesenchymal stromal cells (MSCs) are characterized by a regulatory phenotype and respond promptly to the environmental signals modulating their secretory activity. An appropriate preconditioning may induce MSCs release secretomes with an enhanced regenerative potential. However, it fails take into account that composed both soluble factors extracellular vesicles (EVs), whose functions could be ...

With recent advancements in computational biology, high throughput Next-Generation Sequencing (NGS) has become a de facto standard technology for gene expression studies, including DNAs, RNAs, and proteins; however, it generates several millions of sequences single run. Moreover, the raw sequencing datasets are increasing exponentially, doubling size every 18 months, leading to big data issue b...

Copper is known for its strong biocidal and anti-inflammatory properties, as an accelerator of angiogenesis, cell proliferation secretion Extra Cellular Matrix (ECM) proteins. It therefore excellent candidate in the treatment wounds. The role few factors which presumably mediate copper’s ability to promote wound healing processes already established. However, molecular mechanism by copper facil...

Abstract In the last twenty years Leucine Rich Repeat Kinase 2 (LRRK2) has received immense attention due to its association with several diseases, for example, neurodegenerative disease PD (Parkinson’s Disease), inflammatory bowel (IBD), Crohn’s (CD), infectious Leprosy etc. Not only do genetic mutations make this protein a hotspot various diseases but also it shows some pleotropic characteris...

Abstract Jangkanghwan (JKH) is a Korean traditional food that mixture of ingredients and medicine ingredients, it has been observed to produce satisfactory anti-inflammatory, antioxidant, antibacterial effects. In the current study, JKH was administered by gavage BALB/C mice with lipopolysaccharide (LPS)-induced colonic epithelial dysfunction, mouse body weight intake were recorded. Indexes suc...