Malignant fibrous histiocytoma (MFH) of the gastrointestinal tract is extremely rare. Here we report a case of MFH of the cecum and review other cases of large bowel MFH in the literature. A 64-year-old man had a large tumor mass in the cecum associated with multiple small peritoneal implants. Histologically, most of the lesion showed inflammatory pseudotumor-like appearance; that is, a mixed p...

AN0128 is a boron-containing compound with antibacterial and anti-inflammatory properties. To test its potential effectiveness in treating periodontal disease, we induced experimental periodontitis in the rat by placing ligatures and assessed the impact of AN0128 and positive and negative controls by micro-CT and histologic measurements. The formation of an inflammatory infiltrate was measured ...

A 58-year-old woman with stage 4 adenocarcinoma of the lung being treated with pembrolizumab developed dyspnea, non-productive cough, and a right middle lobe infiltrate. Complete resolution of the infiltrate with cessation of pembrolizumab, initiation of prednisone and no antibiotic therapy suggested drug-associated lung toxicity as the cause. While the programmed death-1 (PD-1) inhibitors -pem...

Dissatisfaction with the final results of treatment patients acute pancreatitis prompts search for new methods diagnosis and therapy this disease. Having experience in surgical 201 various forms pancreatic necrosis, we came to conclusion that classification should reflect state parapancreatic cellular space. This is due following points. First, an extensive purulent-necrotic lesion retroperiton...

Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease characterized by massive immune cell infiltrate, extensive fibrosis, and tissue destruction. We aimed to elucidate the role of fibroblasts in pathophysiology HS. Single-cell RNA-sequencing was performed on chronic lesional samples 6 HS patients 7 controls. Spatial sequencing 4 samples. Fibroblast subclustering revealed subset...

Intrahepatic infiltrate from 18 patients who died of fulminant hepatitis, was analyzed by an immunohistochemical method using formalin-fixed, paraffin-embedded liver sections and monoclonal antibodies. Inflammatory cells were characteristically located in the portal and periportal areas adjoining resting hepatocytes, but were infrequently found in the perivenular areas where hemorrhagic hepatoc...

Histopathological study showed pseudoepitheliomatous hyperplasia of the epidermis and there was a granulomatous inflammatory infiltrate in the dermis composed of histiocytes, eosinophils, and polymorphonuclear cells. Globular structures with a thick, pigmented wall were seen scattered between the inflammatory cells, some of them arranged in the form of a rosary. These structures stained with pe...