An experimental system to explore central tolerance in humans is unavailable. However, the human endogenous retrovirus K-18 (HERV-K18) region on chromosome 1 provides an excellent model: HERV-K18 encodes a superantigen (SAg) stimulating Vbeta7CD4 T cells that is implicated in type 1 diabetes and Epstein-Barr virus persistence. In this study, we have addressed thymic HERV-K18 SAg expression, the...

Previously, through a proteomic analysis, proliferating cell nuclear antigen (PCNA) was found to be overexpressed in the sodium antimony gluconate (SAG)-resistant clinical isolate compared to that in the SAG-sensitive clinical isolate of Leishmania donovani. The present study was designed to explore the potential role of the PCNA protein in SAG resistance in L. donovani. For this purpose, the p...

The paper presents an overview of the current methodology and practice in modeling and control of the grinding process in industrial ball mills. Basic kinetic and energy models of the grinding process are described and the most commonly used control strategies are analyzed and discussed.

In the 19th century, the United Kingdom began a period of economic transformation known as the Industrial Revolution. While the typical reader may think of Dickensian mills when hearing of the Industrial Revolun the 19th century, the United Kingdom began a period of economic transformation known as the Industrial Revolution. It’s commonly believed that this era opened as new inventions improved...

Plugging is well known to be a major cause of instability in industrial cement mills. A simple nonlinear model able to simulate the plugging phenomenon is presented. It is shown how a nonlinear robust controller can be designed in order to fully prevent the mill from plugging.

Introduction. Nowadays, power quality issues are of considerable interest to both utilities and end users as they cause significant financial losses the industrial customers. Due this, assurance in distribution systems is very important, when considering commercial applications. Problem Statement. Unfortunately, sudden faults such sag, transients, harmonics distortion notching system create dis...

This paper proposes a new configuration for the Unified Power Quality Conditioner, which has a DC/DC converter with super-capacitors for energy storage. The proposed UPQC can compensate the reactive power, harmonic current, voltage sag and swell, voltage imbalance, and voltage interruption. The performance of the proposed system was analyzed through simulations with PSCAD/EMTDC software. The fe...

This paper compares two deconvolution methodologies used to estimate residence time distributions (RTD) in industrial closed-circuit ball mills. Parametric and non-parametric techniques were evaluated. Both allowed for direct RTD estimates from inlet outlet tracer measurements the mills, with no need mass balances nor assumptions correct effect of recirculation grinding circuits. Measurements c...