introduction: stress is associated with neurological and cognitive disorders. it has been suggested that doxepin, in addition to its influence on the content of neurotransmitters, has probable neuroprotective effects as well. therefore, the aim of this study was to investigate the effects of doxepin on synaptic plasticity and brain-derived neurotrophic factor (bdnf) gene expression in the rat h...

introduction: different mechanisms are involved in stress induced analgesia (sia) and hyperalgesia (sih). repeated stress induces development of tolerance to sia. the role of hpa axis and gs signaling pathway in these effects are investigated in the current study. methods: forced swim stress (5 min/day) in water (20±1 ºc) was employed to adult male wistar rats (200-250 g). the nociceptive thres...

Objective(s): Hyperglycemia promotes oxidative stress that plays a crucial role in the pathogenesis of Diabetic nephropathy (DN). In this study, we investigated the synergism effects of hydroalcoholic extract of Urtica dioica and pioglitazone (PIO) on the prevention of DN in streptozotocin induced-diabetic mice. Materials and Methods: Forty-two mice were divided into six groups as follows: non-...

conclusions according to the results of this study, the stress level induced due to needle-stick exposure and its complications is high and interventions for reduction are essential. results the mean and standard deviation of stress experienced by nurses before and after the intervention were 64.94 ± 15.67 and 43.91 ± 10.73, respectively. findings indicated that education decrease needle stick ...

objective: oxidative stress that damages proteins result in aging and age related diseases. the aim of this study is to determine the effect of tocotrienol rich fraction (trf) on the expression of proteins in oxidative stress-induced caenohabditis elegans (c.elegans) which has homologous genes to humans. methods: the worms were treated with trf prior to, after and continuously in separate group...

conclusions with regard to the potent antioxidant properties of silymarin, the neuroprotective effects of this natural compound suggested in the current study may in part be mediated through inhibition of oxidative stress. results exposure to acr reduced cell viability in pc12 cells. pre-treatment of cells with silymarin (100 µm) significantly reduced acr-induced toxicity. in addition, administ...