Background. Dalbergia species has wide range of secondary metabolites and is traditionally used in treatment of painful micturition, swelling, and leprosy and as blood tonic. The study evaluates membrane stabilizing, anticoagulant, analgesic, cytotoxic, subacute anti-inflammatory, and depression potentials of D. candenatensis leaves metabolites. Methods. Membrane stabilizing activity was evalua...

The dichloromethane fraction of Hedranthera barteri (DMHBR), a common medicinal plant, was investigated in animal models of depression and anxiety in mice. Graded doses (25-200mg/kg p.o. bw) of DMHBR reduced the immobility time with significant effects produced by 50mg/kg (43.7%), 100mg/kg (45.6%) and 200mg/kg (31.5%) in the tail suspension test (TST) and by 100mg/kg (66.3%) in forced swimming ...

The hydroalcoholic extract of Equisetum arvense (HAE) tested at the doses of 200 and 400 mg/kg showed a significant activity on the open-field, enhanced the number of falls in the rota-rod reducing the time of permanence in the bar and increased the sleeping time (46% and 74%) in the barbiturate-induced sleeping time. In the pentylenetetrazole-seizure, it increased the first convulsion latency,...

Adenine-induced model of chronic kidney disease (CKD) is a widely used model especially in studies testing novel nephroprotective agents. We investigated the effects of adenine-induced CKD in rats on the activities of some xenobiotic metabolizing enzymes in liver and kidneys, and on some in vivo indicators of drug metabolism (viz pentobarbitone sleeping time, and plasma concentration of theophy...

There are few studies on the pharmacological properties of Valeriana prionophylla Standl. (VP), known as "Valeriana del monte", and used in Mesoamerican folk medicine to treat sleep disorders. This study examines the pharmacological effects of the hydroalcoholic extract of the dry rhizome using the open field, rota rod, elevated plus-maze (EPM), forced swimming (FST), strychnine- and pentobarbi...

The plant Wedelia chinensis was found to be used by different traditional systems and folklore for the treatment of various disorders. The aim of the present study is to investigate the effect on central nervous system (CNS) of the ethanol extract of Wedelia chinensis whole plant in Swiss albino mice and Wistar rats.The CNS effects were evaluated by general behaviour, exploratory behaviour, mus...

Asperugo procumbens L. has been used in Iranian traditional medicine for the refreshing, tranquillizing and mood elevating activities. The present study was undertaken to evaluate the antidepressant and sedative-hypnotic potential of acute administration of the hydroalcoholic extract of this plant in mice. Additionally, the effects of flumazenil on the hypnotic activity of the extracts were eva...

In this present study Indian traditional Ayurvedic herbal formulation Amritaristo has been studied to assess the general pharmacological effect on mice. The drug showed no significant activity on the neuropharmacological test models experimented. The increased pentobarbital sleeping time was considered related with hepatic metabolism of pentobarbital. The formulation exhibited a nonsignificant ...

malaria is one the major health problem in nigeria. during pregnancy, it poses serious threat to the survival of both unborn foetus and the mothers. this study determined the effect of adequate malaria knowledge and pregnancy status of women on use of mosquito nets and reported malaria fever morbidity.the data were collected during the malaria indicator survey (mis) from 4632 women. data analys...