The rectal route has proven its worth in terms of achieving successful drug delivery both locally and systematically. primary goal this invention was to develop evaluate Flax suppositories. To administer herbal powder internal sites, suppositories are placed directly into the rectum. A suppository comprises flax as a main active ingredient, administered through route, used laxative, treatment h...

Pain control is a major concern in post-thoracotomy patients. The current prospective randomized double-blind study was designed to evaluate the analgesic effects of morphine and fentanyl given interpleurally after posterolateral thoracotomy. Thirty patients undergoing elective posterolateral thoracotomy in a teaching hospital in Tehran were divided into 3 groups with equal number of patients. ...

TRIAL DESIGN: To compare the difference in pain score during flexible cystoscopy between patients undergoing the procedure with plain lubricating gel  only and plain gel with diclofenac suppository in a randomized control trial. METHODS:  A total of 60 male patients with an indication of flexible cystoscopy were enrolled in a prospective, randomized controlled study. Patients were randomized in...

BACKGROUND Mesalazine suppositories are recommended and widely used as the standard therapy in induction and maintenance of remission for proctitis. AIM To evaluate the efficacy of mesalazine suppositories in patients with ulcerative colitis (UC) and rectal inflammation; and in patient groups categorised by the extent of lesions. METHODS This study was a phase III multicentre, randomised, d...

Pain control is a major concern in post-thoracotomy patients. The current prospective randomized double-blind study was designed to evaluate the analgesic effects of morphine and fentanyl given interpleurally after posterolateral thoracotomy. Thirty patients undergoing elective posterolateral thoracotomy in a teaching hospital in Tehran were divided into 3 groups with equal number of patients. ...

Spectrophotometric method is often recommended in dissolution testing of not only tablets or capsules but also suppositories. Dissolution rate of diclofenac sodium was studied using a pharmacopoeial flow-through apparatus and pH 7.3 buffer. For two lipophilic suppository bases (Witepsol W-32 and H-19) dissolution rate was overestimated with the spectrophotometric zero-order method in comparison...