Five primaquine (PQ) analogues have been isolated by peroxydisulfate oxidation and were tested for antimalarial activity against Plasmodium yoelli infected mice. To develop them as promising antimalarial agents in-silico druglikeness studies were carried out. The analogue 6-Methoxy-5,8-di-(4-amino-1-methylbutyl-amino)-quinoline [P1] was found to be promising antimalarial agent as it was found n...

le besoin croissant de logement et le desir dameliorer la qualite, la securite et la durabilite des batiments, et de diminuer leur prix de revient, ont necessite des recherches etendues dans le domaine des materiaux de la construction. le beton silico-calcaire peut etre considere comme une des reussites remarquables de ces recherches. / le beton silico-calcaire est obtenu par l*acceleation de l...

We have adapted the originally described electronic PCR (e-PCR) algorithm to perform string searches more accurately and much more rapidly than previously possible. Our implementation [multithreaded e-PCR (me-PCR)] runs sufficiently fast to allow even desktop machines to query quickly large genomes with very large genomic element sets. In addition, me-PCR is multithreaded, interprets all IUPAC ...

Medicinal use of the opium poppy (Papaver somniferum L) has ancient history, but the isolation of morphine was not described until the early nineteenth century. Morphine is the most important alkaloid of opium poppy in the last 50 years. In the morphine pathway has been reported to generate morphine in this species, CODM has a crucial role as the gene coding the enzyme respons...

hnf4a-p.i463vvariant, reported previously in two distinct families suspected of mody-1, is assessed in this report to determine whether it is a mutation or a polymorphism (frequency >1%).200 tunisian healthy people were screened for the presence of hnf4a-p.i463v variant, using rflp-pcr technique and sequencing. then, the frequency of this variant was estimated in the tunisian population and com...

introduction: acinetobacter baumannii is associated with hospital-acquired infections. outer membrane protein a of a.baumannii (abompa) is a well-characterized virulence factor which has important roles in pathogenesis of this bacterium. methods: based on our pcr-sequencing of ompa gene in the clinical isolates, abompa protein can be categorized into two types, named here type-1 and type-2. we ...

Endocrine disrupting chemicals pose a significant threat to human health, society and the environment. Many of these chemicals elicit their toxicological effects through nuclear hormone receptors, like the estrogen receptor. Computational tools for predicting receptor mediated effects have been envisaged for their potential to be used for prioritization of chemicals for toxicological evaluation...

Synthetic biology, comprising many aspects including in vivo, in vitro and in silico techniques, models and methods, programming paradigms and tools, is a rapidly growing field with promising potential in building new synthetically constructed devices and systems. Synthetic biology features unconventional biological systems that do not naturally exist in nature. In this paper, we discuss a soft...