نتایج جستجو برای: in silico screening
تعداد نتایج: 17020362 فیلتر نتایج به سال:
Fragile histidine triad (FHIT) serves a critical function as a tumor suppressor that inhibits p53 degradation by mouse double minute 2 (MDM2). The functional domains of FHIT involved in tumor inhibition was interpreted. In-silico screening data were employed to construct truncated forms of FHIT to assess their cytotoxic effects on the HT1080 cell line. Full FHIT expression was confirmed by west...
The detailed kinetic model of Prostaglandin H Synthase-1 (PGHS-1) was applied to in silico screening of dose-dependencies for the different types of nonsteroidal anti-inflammatory drugs (NSAIDs), such as: reversible/irreversible, nonselective/selective to PGHS-1/PGHS-2 and time dependent/independent inhibitors (aspirin, ibuprofen, celecoxib, etc.) The computational screening has shown a signifi...
Submit Manuscript | http://medcraveonline.com Abbreviations: ADME: Absorption, Distribution, Metabolism and Excretion; NDA: New Drug Application; FDA: Food and Drug Administration; CYP: Cytochrome P; UGT: Uridine DiphosphoGlucuronosyl Transferase; NAT: N-Acetyl Transferase; GST: Glutathione S-Transferase; ST: Sulfo Transferase; QSAR: Quantitative Structure–Activity Relationships; PCA: Principal...
Neuroblastoma (NB) is one of the most frequent solid tumors in children and its prognosis is still poor. The neurotrophin receptor TrkB and its ligand brain-derived neurotrophic factor (BDNF) are expressed at high levels in high-risk NBs and are involved in defining the poor prognosis of the patients. However, the TrkB targeting therapy has never been realized in the clinic. We performed an in ...
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