Currently, an estimated 50 million people in the European Union live with multiple chronic diseases (multimorbidity) and this number is expected to further increase in the near future. As multimorbidity deeply impacts on people’s quality of life -physically, but also mentally and socially-, there is a growing demand for multidisciplinary care that is tailored to the specific health and social n...

We introduce two kinds of multiple little q-Jacobi polynomials p~n with multi-index ~n = (n1, n2, . . . , nr) and degree |~n| = n1 + n2 + · · · + nr by imposing orthogonality conditions with respect to r discrete little q-Jacobi measures on the exponential lattice {qk, k = 0, 1, 2, 3, . . .}, where 0 < q < 1. We show that these multiple little qJacobi polynomials have useful q-difference proper...

In this study, a combined electro-(Fenton/coagulation/flotation) (EF/EC/El) process was studied via degradation of Disperse Orange 25 (DO25) organic dye as a case study. Influences of seven operational parameters on the dye removal efficiency (DR%) were measured: initial pH of the solution (pH0), applied voltage between the anode and cathode (V), initial ferrous ion concentration (CFe), initial...

The “bubble universes” of Coleman and De Luccia play a crucial role in string cosmology. Since our own Universe is supposed to be of this kind, bubble cosmology should supply definite answers to the long-standing questions regarding cosmological initial conditions. In particular, it must explain how an initial singularity is avoided, and also how the initial conditions for Inflation were establ...

In the context of regression-based (quarterly) seasonal unit root tests, we examine the impact of initial conditions (one for each quarter) of the process on test power. We investigate the behaviour of the OLS detrended HEGY seasonal unit root tests of Hylleberg et al. (1990) and the corresponding quasi-differenced (QD) detrended tests of Rodrigues and Taylor (2007), when the initial conditions...

A s you know, four main bodies of evidence affirm the big bang: the dark sky, Hubble expansion, element abundances, and cosmic microwave background radiation (CMBR). Parts 1-4 of this series briefly examined these topics. [1-4] Here we say a few words about the window the CMBR offers into the very early universe, including a brief but crucial epoch of " inflation. " Recall that the CMBR was fir...

Most simulation textbooks assume that a model can be started in an empty state and the final output will not be affected, so long as the “warm-up period” is excluded from the analysis. In this paper we test this assumption, using a discrete-event model of a existing manufacturing facility. Using a series of model runs with no initial Work in Progress (WIP) and another series of simulation runs ...